{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["Fund for Excellent Young Scholars of Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine","Fundamental research program funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine","the Innovative Research Team of High-level Local Universities in Shanghai","the Science and Technology Commission of Shanghai","Shanghai Eye Disease Research Center","the National Natural Science Foundation of China"],"pagination":["e17843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(36)"],"pubmed_abstract":["Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls (HC). scRNA-seq data of experimental autoimmune uveitis (EAU) mice are also incorporated. The data showed an altered metabolic profile, characterized by upregulated glycolysis in BU. MYC is predicted to be a hub molecule regulating glycolysis and T cell response. Notably, it is discovered that the expression level of MYC is higher in BU compare to HC and may reflect the treatment response of BU disease. Correspondingly, the scRNA-seq data of EAU mice also reveal hig"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behcet's Uveitis."],"pmcid":["PMC12463086"],"funding_grant_id":["SHSMU745-ZDCX20210902","JYYQ012","JYZZ250","823B2019","17DZ2260100","2022ZZ01003","82401239"],"pubmed_authors":["Zhang G","Peng X","Li H","Li Z","Wang R","Zhu L","Zhang Y","Jia R","Jiang Q","Wu D","Zheng SG","Su W"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behcet's Uveitis.","description":"Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls (HC). scRNA-seq data of experimental autoimmune uveitis (EAU) mice are also incorporated. The data showed an altered metabolic profile, characterized by upregulated glycolysis in BU. MYC is predicted to be a hub molecule regulating glycolysis and T cell response. Notably, it is discovered that the expression level of MYC is higher in BU compare to HC and may reflect the treatment response of BU disease. Correspondingly, the scRNA-seq data of EAU mice also reveal hig","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T20:28:37.71Z","creation":"2026-06-01T03:06:30.418Z"},"accession":"S-EPMC12463086","cross_references":{"pubmed":["40586758"],"doi":["10.1002/advs.202417843"]}}