biostudies-literatureZhang CZhejiang Provincial Science Foundation of ChinaNational Natural Science Foundation of ChinaNingbo Key Research and Development ProgramHuadong Medicine Joint Funds of Zhejiang Provincial Natural Science Foundation of ChinaNingbo Municipal Key Laboratory for Molecular Target Screening and Applicationse14659https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463095biostudies-literatureUnknown12(36)Chronic psychological stress is closely related to myocardial diseases, but the pathological processes and related mechanisms are not yet clear. In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and glucocorticoid receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR, Lama5, is identified and confirmed in vivo and in vitro that the corticosterone-GR-LAMA5 axis is a significant pathway mediating chronic psychological stress-induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a bAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.PMC12463095823003472024Z21081870255LY21H0200012023-BZDSLHDMZ24H020001Wu ZLian JHuang CJin XHu JXu QLin HZhang CYe HSong YZhou JfalseChronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.Chronic psychological stress is closely related to myocardial diseases, but the pathological processes and related mechanisms are not yet clear. In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and glucocorticoid receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR, Lama5, is identified and confirmed in vivo and in vitro that the corticosterone-GR-LAMA5 axis is a significant pathway mediating chronic psychological stress-induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a b2025-01-01T00:00:00Z2025 Sep2026-06-03T20:32:11.785Z2026-05-01T03:10:58.063ZS-EPMC124630954064283810.1002/advs.202414659