{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(9)"],"submitter":["Begum MN"],"pubmed_abstract":["Congenital hypothyroidism (CH), characterized by insufficient thyroid hormone production at birth, is frequently associated with fatigue, particularly in cases with delayed diagnosis. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to profile carnitine and acylcarnitines in late-diagnosed congenital hypothyroid patients receiving levothyroxine (LT4) therapy, with the aim of identifying metabolic alterations that may be associated with fatigue symptoms. A total of 56 late-diagnosed congenital hypothyroid patients and 107 age-, sex-, and BMI-matched healthy controls were enrolled. Blood samples were collected in EDTA tubes and as dried blood spots (DBS) on Whatman® 903 filter paper. LC-MS/MS was used to quantify free carnitine and 28 acylcarnitines, and plasma t"],"journal":["PloS one"],"pagination":["e0331474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463203"],"repository":["biostudies-literature"],"pubmed_title":["Altered carnitine-acylcarnitine profiles in levothyroxine-treated congenital hypothyroid patients with fatigue: An LC-MS/MS-based study from Bangladesh."],"pmcid":["PMC12463203"],"pubmed_authors":["Hasanat MA","Rahat A","Islam ABMMK","Banu H","Qadri F","Ahmed T","Bhuiyan TR","Sarker SK","Begum MN","Akhteruzzaman S","Bhuyan GS","Sultana N","Islam MT","Mannoor K","Patwary MH","Mahtarin R","Konika TK","Qadri SK","Shyamaly KJ","Hasan M","Sajib AA"],"additional_accession":[]},"is_claimable":false,"name":"Altered carnitine-acylcarnitine profiles in levothyroxine-treated congenital hypothyroid patients with fatigue: An LC-MS/MS-based study from Bangladesh.","description":"Congenital hypothyroidism (CH), characterized by insufficient thyroid hormone production at birth, is frequently associated with fatigue, particularly in cases with delayed diagnosis. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to profile carnitine and acylcarnitines in late-diagnosed congenital hypothyroid patients receiving levothyroxine (LT4) therapy, with the aim of identifying metabolic alterations that may be associated with fatigue symptoms. A total of 56 late-diagnosed congenital hypothyroid patients and 107 age-, sex-, and BMI-matched healthy controls were enrolled. Blood samples were collected in EDTA tubes and as dried blood spots (DBS) on Whatman® 903 filter paper. LC-MS/MS was used to quantify free carnitine and 28 acylcarnitines, and plasma t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T20:21:09.341Z","creation":"2026-05-01T03:10:59.493Z"},"accession":"S-EPMC12463203","cross_references":{"pubmed":["40996983"],"doi":["10.1371/journal.pone.0331474"]}}