{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Souza Silva L"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["e0013554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463326"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(9)"],"pubmed_abstract":["Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found tha"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection."],"pmcid":["PMC12463326"],"funding_grant_id":["R01 AI164746","R01 AI079293"],"pubmed_authors":["Golenbock DT","de Souza Silva L","Fitzgerald KA","Gazzinelli RT","Forconi CS","Monks BG","De Paula Tamburro N","Kurt-Jones EA","Crabtree JN"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.","description":"Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found tha","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:19:21.853Z","creation":"2026-05-01T03:10:46.434Z"},"accession":"S-EPMC12463326","cross_references":{"pubmed":["40972121"],"doi":["10.1371/journal.pntd.0013554"]}}