biostudies-literaturede Souza Silva LNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSe0013554https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463326biostudies-literatureUnknown19(9)Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found thaPLoS neglected tropical diseasesInterleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.PMC12463326R01 AI164746R01 AI079293Golenbock DTde Souza Silva LFitzgerald KAGazzinelli RTForconi CSMonks BGDe Paula Tamburro NKurt-Jones EACrabtree JNfalseInterleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found tha2025-01-01T00:00:00Z2025 Sep2026-05-01T03:19:21.853Z2026-05-01T03:10:46.434ZS-EPMC124633264097212110.1371/journal.pntd.0013554