{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bonnifet T"],"funding":["Agence Nationale de la Recherche","Fédération pour la Recherche sur le Cerveau","FONDATION ALZHEIMER","Fondation du Collège de France","Fondation de France","Institut de France"],"pagination":["RP100687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12463392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Recent studies have established a reciprocal causal link between aging and the activation of transposable elements, characterized in particular by a de-repression of LINE-1 retrotransposons. These LINE-1 elements represent 21% of the human genome, but only a minority of these sequences retain the coding potential essential for their mobility. LINE-1 encoded proteins can induce cell toxicity implicated in aging and neurodegenerative diseases. However, our knowledge of the expression and localization of LINE-1-encoded proteins in the central nervous system is limited. Using a novel approach combining atlas-based brain mapping with deep-learning algorithms on large-scale pyramidal brain images, we unveil a heterogeneous, neuron-predominant, and widespread ORF1p expression throughout the murin"],"journal":["eLife"],"pubmed_title":["Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain."],"pmcid":["PMC12463392"],"funding_grant_id":["ANR-20-CE16-0022 NEURAGE","Fondation NRJ","00086320"],"pubmed_authors":["Massiani-Beaudoin O","Loew D","Fuchs J","Sinnassamy S","Monnet H","Joshi RL","Mailly P","Lombard B","Servant N","Bonnifet T"],"additional_accession":[]},"is_claimable":false,"name":"Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain.","description":"Recent studies have established a reciprocal causal link between aging and the activation of transposable elements, characterized in particular by a de-repression of LINE-1 retrotransposons. These LINE-1 elements represent 21% of the human genome, but only a minority of these sequences retain the coding potential essential for their mobility. LINE-1 encoded proteins can induce cell toxicity implicated in aging and neurodegenerative diseases. However, our knowledge of the expression and localization of LINE-1-encoded proteins in the central nervous system is limited. Using a novel approach combining atlas-based brain mapping with deep-learning algorithms on large-scale pyramidal brain images, we unveil a heterogeneous, neuron-predominant, and widespread ORF1p expression throughout the murin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:11:09.42Z","creation":"2026-05-01T03:11:06.687Z"},"accession":"S-EPMC12463392","cross_references":{"pubmed":["40996791"],"doi":["10.7554/eLife.100687"]}}