{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Ren J"],"pubmed_abstract":["Lung cancer ranks among the top causes of cancer-related deaths globally. Prompt diagnosis and timely intervention play a vital role in enhancing patient prognosis and increasing survival chances. Although C15ORF48 expression is generally elevated in tumor tissues, it is reduced in specific cancers like colorectal cancer, and its role across pan-cancer remains unclear. This research investigates the expression, immune infiltration, and predictive significance of C15ORF48 in pan-cancer using multiple databases, including TIMER2.0, GEPIA, and the Human Protein Atlas. Additionally, we use cBioPortal, PhosphoNET, and AlphaFold to analyze the distribution of genetic alterations, phosphorylation sites, and pathogenic hotspots in C15ORF48. C15ORF48 expression is generally elevated in tumor versus"],"journal":["Scientific reports"],"pagination":["32821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464244"],"repository":["biostudies-literature"],"pubmed_title":["C15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer."],"pmcid":["PMC12464244"],"pubmed_authors":["Liu M","Ren J","Mao W","Zhu H","Zhang R","Xiao S"],"additional_accession":[]},"is_claimable":false,"name":"C15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer.","description":"Lung cancer ranks among the top causes of cancer-related deaths globally. Prompt diagnosis and timely intervention play a vital role in enhancing patient prognosis and increasing survival chances. Although C15ORF48 expression is generally elevated in tumor tissues, it is reduced in specific cancers like colorectal cancer, and its role across pan-cancer remains unclear. This research investigates the expression, immune infiltration, and predictive significance of C15ORF48 in pan-cancer using multiple databases, including TIMER2.0, GEPIA, and the Human Protein Atlas. Additionally, we use cBioPortal, PhosphoNET, and AlphaFold to analyze the distribution of genetic alterations, phosphorylation sites, and pathogenic hotspots in C15ORF48. C15ORF48 expression is generally elevated in tumor versus","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:09:10.876Z","creation":"2026-05-01T03:10:58.419Z"},"accession":"S-EPMC12464244","cross_references":{"pubmed":["40998903"],"doi":["10.1038/s41598-025-17966-3"]}}