{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["46(4)"],"submitter":["Shen BG"],"pubmed_abstract":["In adult mammals, optic nerve injury leads to irreversible vision loss due to its extremely limited regenerative capacity. In contrast, adult zebrafish possess a robust capacity for spontaneous visual system regeneration, although the spatiotemporal coordination of recovery across the retina, optic nerve, and brain remains poorly understood. In the present study, the regenerative dynamics following optic nerve transection were systematically characterized in adult zebrafish over a 5 week period using hematoxylin-eosin staining, immunohistochemistry, transmission electron microscopy, single-cell RNA sequencing, and optokinetic response (OKR) behavioral assessments. At 1 week post-injury (1 wpi), retinal ganglion cell depletion was evident but showed significant recovery by 2 wpi. Concurrent"],"journal":["Zoological research"],"pagination":["733-749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464375"],"repository":["biostudies-literature"],"pubmed_title":["From injury to recovery: Spatiotemporal dynamics of the visual pathway during spontaneous structural and functional regeneration after optic nerve transection in zebrafish."],"pmcid":["PMC12464375"],"pubmed_authors":["Wen Y","Wu WC","Wei HY","Huang SR","Zhang YK","Zhou GM","Shen BG","Lu SJ","Yan WT"],"additional_accession":[]},"is_claimable":false,"name":"From injury to recovery: Spatiotemporal dynamics of the visual pathway during spontaneous structural and functional regeneration after optic nerve transection in zebrafish.","description":"In adult mammals, optic nerve injury leads to irreversible vision loss due to its extremely limited regenerative capacity. In contrast, adult zebrafish possess a robust capacity for spontaneous visual system regeneration, although the spatiotemporal coordination of recovery across the retina, optic nerve, and brain remains poorly understood. In the present study, the regenerative dynamics following optic nerve transection were systematically characterized in adult zebrafish over a 5 week period using hematoxylin-eosin staining, immunohistochemistry, transmission electron microscopy, single-cell RNA sequencing, and optokinetic response (OKR) behavioral assessments. At 1 week post-injury (1 wpi), retinal ganglion cell depletion was evident but showed significant recovery by 2 wpi. Concurrent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-16T21:52:26.617Z","creation":"2026-07-10T03:15:57.86Z"},"accession":"S-EPMC12464375","cross_references":{"pubmed":["40567162"],"doi":["10.24272/j.issn.2095-8137.2025.020"]}}