biostudies-literatureUnknown13Yang B<h4>Background</h4>To bridge the gap between clinical guidelines and suboptimal stroke management in rural settings, we conducted an implementation trial using evidence-based, mobile health-enabled strategies to empower primary care providers in rural China. The system-integrated and digital technology-enabled model of care (SINEMA) model was shown to significantly reduce blood pressure and mortality among people with stroke in rural China.<h4>Objective</h4>This study aimed to evaluate the cost-effectiveness of the SINEMA intervention within both the active trial and the post-trial observational periods and its budget impact for potential nationwide scalability.<h4>Methods</h4>In the cluster-randomized implementation trial (the SINEMA trial), 50 villages were randomized to either a 1-year JMIR mHealth and uHealthe75326https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464504biostudies-literatureEconomic Evaluation of a Multicomponent mHealth Intervention for Stroke Management in Rural China: Cluster-Randomized Trial With 6-Year Follow-Up.PMC12464504Finkelstein ESi LTan JCai JYang BChen CGong EDong DLi YYan LLOldenburg BZhang XChen XPeoples NfalseEconomic Evaluation of a Multicomponent mHealth Intervention for Stroke Management in Rural China: Cluster-Randomized Trial With 6-Year Follow-Up.<h4>Background</h4>To bridge the gap between clinical guidelines and suboptimal stroke management in rural settings, we conducted an implementation trial using evidence-based, mobile health-enabled strategies to empower primary care providers in rural China. The system-integrated and digital technology-enabled model of care (SINEMA) model was shown to significantly reduce blood pressure and mortality among people with stroke in rural China.<h4>Objective</h4>This study aimed to evaluate the cost-effectiveness of the SINEMA intervention within both the active trial and the post-trial observational periods and its budget impact for potential nationwide scalability.<h4>Methods</h4>In the cluster-randomized implementation trial (the SINEMA trial), 50 villages were randomized to either a 1-year 2025-01-01T00:00:00Z2025 Sep2026-06-03T21:21:41.786Z2026-05-01T03:10:55.427ZS-EPMC124645044093449510.2196/75326