biostudies-literatureUnknown8(9)Horwitz LI<h4>Importance</h4>Olfactory dysfunction is common after SARS-CoV-2 infection and has been associated with cognitive loss in other conditions. Formal testing is needed to characterize the presence, severity, and patterns of olfactory dysfunction.<h4>Objective</h4>To characterize long-term olfactory dysfunction after SARS-CoV-2 infection.<h4>Design, setting, and participants</h4>This prospective cohort study included adults enrolled in the Researching COVID to Enhance Recovery (RECOVER)-Adult study. All those with and a random sample of those without self-reported change or loss in smell or taste were offered olfactory testing, performed at 83 sites in 35 US states and territories. Participants included 2956 enrollees with prior infection (1393 with and 1563 without self-reported change or JAMA network opene2533815https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464792biostudies-literatureOlfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.PMC12464792Bailey CAnglin KCapo GRyder DZaretsky JLinas BWilensky RKrishnamoorthy AZaldivar MFischer LMCruz Irving AKaneko JEdmark RHaas JWest JNHines DSembajwe RFournier CNPoussier RHasek SPasquarelli DAlekhina NKapogiannis CRoyster JPerez Frontera SPhillips-Lorenzo EIngram KDBassett IVCarton TWSowles AMinor TMcCray NAriri CShaukat ABolecek JHarkins MSFlaherman VSchilkrut DDaniel CLYuan DLewczak ZAJuarez MPeralta-Carcelen MBerger PStein-Seroussi DErlandson KMHartley WHoh RSylvera ANoland SWongtrakool CTartt NDeswal MHartwig KSandoval GJAlmenana RShinnick DJQuintero OGarcia-Sastre AMerad MBremner JDWhite SSaffian EHang TPUnterberger KPrendergast HMGross RSGillespie MBengtson CHoward THeath JRHoffman 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HAguilar FAJames JAKoleski AKerr JDKleinhenz DSoto FBrim HChurch RSorochinsky CHarteloo ARahman KPerez NLBurrell NPClinton KMendis MKominiarek MAPrasad BLambert BVaccarino VLu JRosolowski BSpivak AMVasey ADeeks SGLong EBeckmann NDSanchez Vazquez WMann MNAbella JAhirwar SRogers CLanke GBull RNguyen TKirkwood LCiriello MMaroney MOkada ANguyen KMacFadden DHolmes VJennette KJNguyen HNelsen ALRowley MPant DLutrick KEdberg JBreiter TAzor-Sterlin MfalseOlfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.<h4>Importance</h4>Olfactory dysfunction is common after SARS-CoV-2 infection and has been associated with cognitive loss in other conditions. Formal testing is needed to characterize the presence, severity, and patterns of olfactory dysfunction.<h4>Objective</h4>To characterize long-term olfactory dysfunction after SARS-CoV-2 infection.<h4>Design, setting, and participants</h4>This prospective cohort study included adults enrolled in the Researching COVID to Enhance Recovery (RECOVER)-Adult study. All those with and a random sample of those without self-reported change or loss in smell or taste were offered olfactory testing, performed at 83 sites in 35 US states and territories. Participants included 2956 enrollees with prior infection (1393 with and 1563 without self-reported change or 2025-01-01T00:00:00Z2025 Sep2026-06-03T21:08:58.682Z2026-05-01T03:10:56.547ZS-EPMC124647924099675910.1001/jamanetworkopen.2025.33815