biostudies-literatureUnknown12(9)Sada RM<h4>Background</h4>Natto consumption has been associated with improved cardiovascular and survival outcomes. <i>Bacillus subtilis</i> variant <i>natto</i> (<i>B. subtilis</i> var. <i>natto</i>) is essential for soybean fermentation in natto production. Recently, several cases of <i>B. subtilis</i> var. <i>natto</i> bacteremia have been reported, although the contribution of <i>B. subtilis</i> var. <i>natto</i> remains unclear. This study assessed the prevalence and clinical impact of <i>B. subtilis</i> var. <i>natto</i> in <i>B. subtilis</i> bacteremia.<h4>Methods</h4>This retrospective cohort study analyzed medical records of patients with positive <i>B. subtilis</i> blood cultures at Tenri Hospital from 1 April 2016 to 31 March 2023. True bacteremia required portal-of-entry or, for intraOpen forum infectious diseasesofaf574https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464813biostudies-literatureThe Majority of <i>Bacillus subtilis</i> Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto: A Single-center Retrospective Study.PMC12464813Abe NOkura AHamaguchi SYamamoto GCai MNakanishi KKutsuna SSada RMYamamoto SKuroda EfalseThe Majority of <i>Bacillus subtilis</i> Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto: A Single-center Retrospective Study.<h4>Background</h4>Natto consumption has been associated with improved cardiovascular and survival outcomes. <i>Bacillus subtilis</i> variant <i>natto</i> (<i>B. subtilis</i> var. <i>natto</i>) is essential for soybean fermentation in natto production. Recently, several cases of <i>B. subtilis</i> var. <i>natto</i> bacteremia have been reported, although the contribution of <i>B. subtilis</i> var. <i>natto</i> remains unclear. This study assessed the prevalence and clinical impact of <i>B. subtilis</i> var. <i>natto</i> in <i>B. subtilis</i> bacteremia.<h4>Methods</h4>This retrospective cohort study analyzed medical records of patients with positive <i>B. subtilis</i> blood cultures at Tenri Hospital from 1 April 2016 to 31 March 2023. True bacteremia required portal-of-entry or, for intra2025-01-01T00:00:00Z2025 Sep2026-05-02T03:15:50.074Z2026-05-02T03:10:45.376ZS-EPMC124648134101869510.1093/ofid/ofaf574