{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang T"],"funding":["Natural Science Foundation of Hunan Province","National Natural Science Foundation of China","University of South China"],"pagination":["gkaf972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464824"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(18)"],"pubmed_abstract":["Alternative splicing (AS) regulates the diversity and level of the proteome. The specificity in AS is in turn regulated by RNA-binding proteins, but our understanding of how they act is far from complete. Here, we identify the Angel wing (Anw) protein, previously CG10948, as a novel AS regulator. Loss of Anw in Drosophila disrupts splicing in muscle genes and subsequently muscle function. Based on a mini-gene assay in which Anw and its RNA targets are co-expressed in cultured cells, we demonstrated orthologous splicing regulation of the mini-gene transcripts, interaction between Anw and its RNA targets, and a remarkable functional conservation among Anw homologs. Anw forms nuclear foci, and genetic ablation of Anw domains suggests that maintaining distinctive features of these foci is impo"],"journal":["Nucleic acids research"],"pubmed_title":["Angel wing: a class of alternative splicing regulators in animals."],"pmcid":["PMC12464824"],"funding_grant_id":["3221101328","2023JJ40536"],"pubmed_authors":["Cui M","Rong YS","Zhang T","Tan X","Xiao Y","Li K"],"additional_accession":[]},"is_claimable":false,"name":"Angel wing: a class of alternative splicing regulators in animals.","description":"Alternative splicing (AS) regulates the diversity and level of the proteome. The specificity in AS is in turn regulated by RNA-binding proteins, but our understanding of how they act is far from complete. Here, we identify the Angel wing (Anw) protein, previously CG10948, as a novel AS regulator. Loss of Anw in Drosophila disrupts splicing in muscle genes and subsequently muscle function. Based on a mini-gene assay in which Anw and its RNA targets are co-expressed in cultured cells, we demonstrated orthologous splicing regulation of the mini-gene transcripts, interaction between Anw and its RNA targets, and a remarkable functional conservation among Anw homologs. Anw forms nuclear foci, and genetic ablation of Anw domains suggests that maintaining distinctive features of these foci is impo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-30T03:33:10.41Z","creation":"2026-06-30T03:28:23.305Z"},"accession":"S-EPMC12464824","cross_references":{"pubmed":["41002027"],"doi":["10.1093/nar/gkaf972"]}}