{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang C"],"funding":["Project for Development of TCM Science and Technology of Shandong Province","Special Emergency research and development of Social Benefiting Technology Program, Qingdao","Jinan City Funding for University Innovation Teams","Major Basic Program of Natural Science Foundation of Shandong Province"],"pagination":["1364-1375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12464867"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(8)"],"pubmed_abstract":["Background
Qi pi pill (QPP), which contains Renshen, Baizhu, Fuling, Gancao, Chenpi, Shanyao, Lianzi, Shanzha, Liushenqu, Maiya, and Zexie, was recommended for preventing and treating COVID-19 in Shandong Province (China). However, the mechanism by which QPP treats infectious diseases remains unclear. This study aims to investigate the therapeutic effect of QPP in vitro and on acute influenza infection in mice, exploring its mechanism of action against influenza A virus (IAV).Methods
The in vitro activity of QPP was assessed using dose-response curve analysis and titer reduction assay, and its antiviral mechanism was identified in vitro by real-time polymerase chain reaction (PCR), time-of-addition, and enzymatic assays. The antiviral efficacy of QPP was further evaluated i"],"journal":["Animal models and experimental medicine"],"pubmed_title":["Antiviral effects and mechanism of Qi pi pill against influenza viruses."],"pmcid":["PMC12464867"],"funding_grant_id":["ZR2021ZD17","M-2022145","2021GXRC028","23-7-8-smjk-3-nsh"],"pubmed_authors":["Tian J","Du R","Lian X","Fan L","Dong M","Gao J","Li P","Zhang C","Cui Q","Sacramento CQ","Rong L"],"additional_accession":[]},"is_claimable":false,"name":"Antiviral effects and mechanism of Qi pi pill against influenza viruses.","description":"Background
Qi pi pill (QPP), which contains Renshen, Baizhu, Fuling, Gancao, Chenpi, Shanyao, Lianzi, Shanzha, Liushenqu, Maiya, and Zexie, was recommended for preventing and treating COVID-19 in Shandong Province (China). However, the mechanism by which QPP treats infectious diseases remains unclear. This study aims to investigate the therapeutic effect of QPP in vitro and on acute influenza infection in mice, exploring its mechanism of action against influenza A virus (IAV).Methods
The in vitro activity of QPP was assessed using dose-response curve analysis and titer reduction assay, and its antiviral mechanism was identified in vitro by real-time polymerase chain reaction (PCR), time-of-addition, and enzymatic assays. The antiviral efficacy of QPP was further evaluated i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-03T20:21:35.556Z","creation":"2026-05-01T03:11:03.523Z"},"accession":"S-EPMC12464867","cross_references":{"pubmed":["39865580"],"doi":["10.1002/ame2.12511"]}}