biostudies-literatureMcLendon JMAmerican Heart AssociationNHLBI NIH HHSNational Institutes of HealthRoy J. and Lucille A. Carver College of Medicine, University of Iowa56-69https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465015biostudies-literatureUnknown201Centrosomes localize to perinuclear foci where they serve multifunctional roles, arranging the microtubule organizing center (MTOC) and anchoring ubiquitin proteasome system (UPS) machinery, as suggested by prior studies. In mature cardiomyocytes, centrosomal proteins redistribute into a specialized perinuclear cage-like structure, and a potential centrosomal-UPS interface has not been studied, despite established roles for UPS in cardiomyopathy. In addition, there have been no reports citing cardiomyocyte UPS dysfunction upon or after manipulation of centrosomal proteins. Taxilin-beta (Txlnb), a cardiomyocyte-enriched protein, belongs to a family of centrosome adapter proteins implicated in protein quality control. We hypothesize that Txlnb is part of the perinuclear centrosomal cage and Journal of molecular and cellular cardiologyGain and loss of the centrosomal protein taxilin-beta influences cardiac proteostasis and stress.PMC12465015R01-HL150557R01-HL144717R01 HL148796R01 HL144717T32-HL007121R01-HL14879619POST34380640R01 HL150557T32 HL007121Baehr LMBoudreau RLMcLendon JMZhang XBodine SCStein CSfalseGain and loss of the centrosomal protein taxilin-beta influences cardiac proteostasis and stress.Centrosomes localize to perinuclear foci where they serve multifunctional roles, arranging the microtubule organizing center (MTOC) and anchoring ubiquitin proteasome system (UPS) machinery, as suggested by prior studies. In mature cardiomyocytes, centrosomal proteins redistribute into a specialized perinuclear cage-like structure, and a potential centrosomal-UPS interface has not been studied, despite established roles for UPS in cardiomyopathy. In addition, there have been no reports citing cardiomyocyte UPS dysfunction upon or after manipulation of centrosomal proteins. Taxilin-beta (Txlnb), a cardiomyocyte-enriched protein, belongs to a family of centrosome adapter proteins implicated in protein quality control. We hypothesize that Txlnb is part of the perinuclear centrosomal cage and 2025-01-01T00:00:00Z2025 Apr2026-07-09T10:24:57.986Z2026-07-09T10:18:22.272ZS-EPMC124650154001043010.1016/j.yjmcc.2025.02.008