{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Hayashi M"],"pubmed_abstract":["<h4>Background</h4>Optimal timing for treatment initiation in <i>Mycobacterium avium</i> complex pulmonary disease (MAC-PD) remains unclear due to lack of established rules for predicting treatment response.<h4>Methods</h4>A retrospective observational study was conducted to develop a prediction model for treatment failure at 2 Japanese university hospitals between 2012 and 2023. Participants were 135 patients with MAC-PD who received macrolides and ethambutol-containing regimens over 1 year. Treatment failure was defined as nonachievement culture conversion at 1 year. We selected model components as cavity (categorized by diameter) and bronchiectasis (categorized by modified Reiff score) on pretreatment computed tomography. Their combinations of each category were scored based on number o"],"journal":["Open forum infectious diseases"],"pagination":["ofaf565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465108"],"repository":["biostudies-literature"],"pubmed_title":["Developing a Simple Scoring System on CT Findings for Predicting Treatment Failure in &lt;i&gt;Mycobacterium avium&lt;/i&gt; Complex Pulmonary Disease: The BCD (Bronchiectasis and Cavity Distribution) Score."],"pmcid":["PMC12465108"],"pubmed_authors":["Matsukura S","Cho H","Yokoe T","Takishima H","Yamaguchi F","Hayashi M"],"additional_accession":[]},"is_claimable":false,"name":"Developing a Simple Scoring System on CT Findings for Predicting Treatment Failure in &lt;i&gt;Mycobacterium avium&lt;/i&gt; Complex Pulmonary Disease: The BCD (Bronchiectasis and Cavity Distribution) Score.","description":"<h4>Background</h4>Optimal timing for treatment initiation in <i>Mycobacterium avium</i> complex pulmonary disease (MAC-PD) remains unclear due to lack of established rules for predicting treatment response.<h4>Methods</h4>A retrospective observational study was conducted to develop a prediction model for treatment failure at 2 Japanese university hospitals between 2012 and 2023. Participants were 135 patients with MAC-PD who received macrolides and ethambutol-containing regimens over 1 year. Treatment failure was defined as nonachievement culture conversion at 1 year. We selected model components as cavity (categorized by diameter) and bronchiectasis (categorized by modified Reiff score) on pretreatment computed tomography. Their combinations of each category were scored based on number o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:41:11.319Z","creation":"2026-05-02T03:08:14.24Z"},"accession":"S-EPMC12465108","cross_references":{"pubmed":["41018706"],"doi":["10.1093/ofid/ofaf565"]}}