{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qigen X"],"funding":["National Natural Science Foundation of China","Medical Research Funding of Guangdong"],"pagination":["70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465185"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed Lhcgr<sup>W495X/+</sup> (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to prenatal Di-(2-ethylhexyl) phthalate (DEHP) exposure, a model designed to investigate steroidogenic gene expression in gene-environment interactions.<h4>Methods</h4>Pregnant wild-type (WT) dams (mated with Lhcgr<sup>W495X/+</sup> heterozygote (HET) received varying levels of DEHP: no exposure, low-dose (100 mg/kg/d) DEHP, and high-dose (1000 mg/kg/d) DEHP during gestation, which led to prenatal exposure in male offspring. Male offspring were divided into HET (Lhcgr<sup>W495X/+</sup>) and WT groups based on genotype in thr"],"journal":["Biology of sex differences"],"pubmed_title":["Genetic variants (Lhcgr&lt;sup&gt;W495X/+&lt;/sup&gt;) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression."],"pmcid":["PMC12465185"],"funding_grant_id":["A2022499","81971314"],"pubmed_authors":["Qigen X","Haiming C","Kai X","Yong G","Zhe X","Chunhua D"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variants (Lhcgr&lt;sup&gt;W495X/+&lt;/sup&gt;) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression.","description":"<h4>Background</h4>Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed Lhcgr<sup>W495X/+</sup> (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to prenatal Di-(2-ethylhexyl) phthalate (DEHP) exposure, a model designed to investigate steroidogenic gene expression in gene-environment interactions.<h4>Methods</h4>Pregnant wild-type (WT) dams (mated with Lhcgr<sup>W495X/+</sup> heterozygote (HET) received varying levels of DEHP: no exposure, low-dose (100 mg/kg/d) DEHP, and high-dose (1000 mg/kg/d) DEHP during gestation, which led to prenatal exposure in male offspring. Male offspring were divided into HET (Lhcgr<sup>W495X/+</sup>) and WT groups based on genotype in thr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:16:56.045Z","creation":"2026-05-02T03:08:43.613Z"},"accession":"S-EPMC12465185","cross_references":{"pubmed":["41013757"],"doi":["10.1186/s13293-025-00753-0"]}}