{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Liu S"],"pubmed_abstract":["Ferroptosis is emerging as a promising therapeutic strategy for glioblastoma (GBM). However, insufficient lipid peroxidation levels and blood-brain barrier (BBB) pose a significant challenge for GBM treatment. Here, we present natural product luteolin (Lut)-coordinated Fe<sup>3+</sup> nanoparticles loaded with dihydroartemisinin (DHA), designated as FLD NPs, which can cross the BBB and induce quadruple amplified ferroptosis. Specifically, FLD NPs leverage four mechanisms to enhance ferroptosis: (1) Lut upregulates heme oxygenase 1 (HO-1), promoting heme degradation and recruiting endogenous Fe<sup>2+</sup>. (2) exogenous Fe<sup>3+</sup> depletes glutathione (GSH), increasing Fe<sup>2+</sup> levels and catalyzing H<sub>2</sub>O<sub>2</sub> to generate ·OH via the Fenton reaction; (3) Fe<sup"],"journal":["Journal of nanobiotechnology"],"pagination":["605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465256"],"repository":["biostudies-literature"],"pubmed_title":["Quadruple synergistic amplification of ferroptosis for precision glioblastoma therapy: a luteolin-coordinated ferric ion nanoplatform."],"pmcid":["PMC12465256"],"pubmed_authors":["Liu X","Chang YX","Wang P","Wang B","Peng B","Yu XA","Liu S","Li M","Sun K"],"additional_accession":[]},"is_claimable":false,"name":"Quadruple synergistic amplification of ferroptosis for precision glioblastoma therapy: a luteolin-coordinated ferric ion nanoplatform.","description":"Ferroptosis is emerging as a promising therapeutic strategy for glioblastoma (GBM). However, insufficient lipid peroxidation levels and blood-brain barrier (BBB) pose a significant challenge for GBM treatment. Here, we present natural product luteolin (Lut)-coordinated Fe<sup>3+</sup> nanoparticles loaded with dihydroartemisinin (DHA), designated as FLD NPs, which can cross the BBB and induce quadruple amplified ferroptosis. Specifically, FLD NPs leverage four mechanisms to enhance ferroptosis: (1) Lut upregulates heme oxygenase 1 (HO-1), promoting heme degradation and recruiting endogenous Fe<sup>2+</sup>. (2) exogenous Fe<sup>3+</sup> depletes glutathione (GSH), increasing Fe<sup>2+</sup> levels and catalyzing H<sub>2</sub>O<sub>2</sub> to generate ·OH via the Fenton reaction; (3) Fe<sup","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:23:29.935Z","creation":"2026-05-01T03:11:06.501Z"},"accession":"S-EPMC12465256","cross_references":{"pubmed":["40999469"],"doi":["10.1186/s12951-025-03688-1"]}}