{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(1)"],"submitter":["Tekoh TA"],"pubmed_abstract":["Metabolic resistance to pyrethroids driven by cytochrome P450s is threatening malaria control interventions and may provide cross-resistance to insecticides with unrelated modes of action. Here, we show that cytochrome P450 genes CYP6P9a/b associated with pyrethroid resistance in Anopheles funestus also confer cross-resistance to a novel mitochondrial complex I inhibitor insecticide, code-named Sherlock. Using standard bioassays (CDC bottle bioassays, WHO cone bioassays, and WHO tunnel tests), the Sherlock and pyrethroid insecticides were tested against pyrethroid-resistant An. gambiae s.s. (Nkolondom, Cameroon) and An. funestus s.s. (Mibellon, Cameroon) and FUMOZ-R). Molecular assays (genotyping of P450 markers and qRT-PCR expression) were performed to investigate the underlying resistanc"],"journal":["BMC genomics"],"pagination":["837"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465288"],"repository":["biostudies-literature"],"pubmed_title":["The duplicated cytochrome P450 CYP6P9a/b confers cross-resistance to a mitochondrial complex I inhibitor in the African malaria vector Anopheles funestus."],"pmcid":["PMC12465288"],"pubmed_authors":["Tekoh TA","Tchouakui M","Small G","Menze B","Tchapga W","Wondji M","Mugenzi LMJ","Wondji CS"],"additional_accession":[]},"is_claimable":false,"name":"The duplicated cytochrome P450 CYP6P9a/b confers cross-resistance to a mitochondrial complex I inhibitor in the African malaria vector Anopheles funestus.","description":"Metabolic resistance to pyrethroids driven by cytochrome P450s is threatening malaria control interventions and may provide cross-resistance to insecticides with unrelated modes of action. Here, we show that cytochrome P450 genes CYP6P9a/b associated with pyrethroid resistance in Anopheles funestus also confer cross-resistance to a novel mitochondrial complex I inhibitor insecticide, code-named Sherlock. Using standard bioassays (CDC bottle bioassays, WHO cone bioassays, and WHO tunnel tests), the Sherlock and pyrethroid insecticides were tested against pyrethroid-resistant An. gambiae s.s. (Nkolondom, Cameroon) and An. funestus s.s. (Mibellon, Cameroon) and FUMOZ-R). Molecular assays (genotyping of P450 markers and qRT-PCR expression) were performed to investigate the underlying resistanc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:45:37.455Z","creation":"2026-05-02T03:08:39.316Z"},"accession":"S-EPMC12465288","cross_references":{"pubmed":["41013195"],"doi":["10.1186/s12864-025-11984-1"]}}