{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Pei T"],"pubmed_abstract":["This study leverages NHANES data to examine the relationship between methylmalonic acid (MMA), a marker of mitochondrial dysfunction, and bone mineral density (BMD). Multivariable linear regression reveals a negative correlation between log10-transformed MMA(Log10 MMA) levels and BMD, along with nonlinear dose-response relationships. Elevated MMA levels are associated with lower BMD, suggesting a negative impact on bone health and highlighting the importance of metabolic regulation in osteoporosis prevention and areas for further research.<h4>Methods</h4>Using NHANES data, multivariable linear regression analyzed the association between log10-transformed MMA levels and BMD, considering covariates like age, race and education. MEC weights were applied to adjust for the complex survey design"],"journal":["Journal of orthopaedic surgery and research"],"pagination":["842"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465394"],"repository":["biostudies-literature"],"pubmed_title":["Serum methylmalonic acid levels predict multisite bone mineral density decline in patients with suspected mitochondrial dysfunction."],"pmcid":["PMC12465394"],"pubmed_authors":["Lei Y","Wu P","Gao Y","Liu Q","Hao X","Pei T"],"additional_accession":[]},"is_claimable":false,"name":"Serum methylmalonic acid levels predict multisite bone mineral density decline in patients with suspected mitochondrial dysfunction.","description":"This study leverages NHANES data to examine the relationship between methylmalonic acid (MMA), a marker of mitochondrial dysfunction, and bone mineral density (BMD). Multivariable linear regression reveals a negative correlation between log10-transformed MMA(Log10 MMA) levels and BMD, along with nonlinear dose-response relationships. Elevated MMA levels are associated with lower BMD, suggesting a negative impact on bone health and highlighting the importance of metabolic regulation in osteoporosis prevention and areas for further research.<h4>Methods</h4>Using NHANES data, multivariable linear regression analyzed the association between log10-transformed MMA levels and BMD, considering covariates like age, race and education. MEC weights were applied to adjust for the complex survey design","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:36:44.538Z","creation":"2026-05-02T03:07:47.491Z"},"accession":"S-EPMC12465394","cross_references":{"pubmed":["41013755"],"doi":["10.1186/s13018-025-06246-5"]}}