biostudies-literatureUnknown20(1)Pei TThis study leverages NHANES data to examine the relationship between methylmalonic acid (MMA), a marker of mitochondrial dysfunction, and bone mineral density (BMD). Multivariable linear regression reveals a negative correlation between log10-transformed MMA(Log10 MMA) levels and BMD, along with nonlinear dose-response relationships. Elevated MMA levels are associated with lower BMD, suggesting a negative impact on bone health and highlighting the importance of metabolic regulation in osteoporosis prevention and areas for further research.<h4>Methods</h4>Using NHANES data, multivariable linear regression analyzed the association between log10-transformed MMA levels and BMD, considering covariates like age, race and education. MEC weights were applied to adjust for the complex survey designJournal of orthopaedic surgery and research842https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465394biostudies-literatureSerum methylmalonic acid levels predict multisite bone mineral density decline in patients with suspected mitochondrial dysfunction.PMC12465394Lei YWu PGao YLiu QHao XPei TfalseSerum methylmalonic acid levels predict multisite bone mineral density decline in patients with suspected mitochondrial dysfunction.This study leverages NHANES data to examine the relationship between methylmalonic acid (MMA), a marker of mitochondrial dysfunction, and bone mineral density (BMD). Multivariable linear regression reveals a negative correlation between log10-transformed MMA(Log10 MMA) levels and BMD, along with nonlinear dose-response relationships. Elevated MMA levels are associated with lower BMD, suggesting a negative impact on bone health and highlighting the importance of metabolic regulation in osteoporosis prevention and areas for further research.<h4>Methods</h4>Using NHANES data, multivariable linear regression analyzed the association between log10-transformed MMA levels and BMD, considering covariates like age, race and education. MEC weights were applied to adjust for the complex survey design2025-01-01T00:00:00Z2025 Sep2026-06-03T21:36:44.538Z2026-05-02T03:07:47.491ZS-EPMC124653944101375510.1186/s13018-025-06246-5