{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin W"],"funding":["National Natural Science Foundation of China","Self-financed scientific research of Guangxi Zhuang Autonomous Region Health Commission"],"pagination":["1155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465621"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Cryptococcus neoformansis widely distributed in nature and primarily causes infections in various parts of the body through inhalation into the lungs. While C.neoformans infection predominantly occurs in immunocompromised individuals, there has been a significant increase in reports among immunocompetent hosts in recent years. Although the lungs and central nervous system constitute the most common sites of infection, cryptococcal osteomyelitis remains exceptionally rare and is typically associated with disseminated disease in immunodeficient patients. Herein, we present a rare case of isolated tibial cryptococcal osteomyelitis in an immunocompetent patient.<h4>Case presentation</h4>We report a case of a 64-year-old female who presented with pain, swelling, and increased"],"journal":["BMC infectious diseases"],"pubmed_title":["Cryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS."],"pmcid":["PMC12465621"],"funding_grant_id":["82360412","NO.Z-A20240638"],"pubmed_authors":["Zhou L","Guo Y","Liang Z","Huang H","Tan S","Xie L","Wei H","Qin W","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Cryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS.","description":"<h4>Background</h4>Cryptococcus neoformansis widely distributed in nature and primarily causes infections in various parts of the body through inhalation into the lungs. While C.neoformans infection predominantly occurs in immunocompromised individuals, there has been a significant increase in reports among immunocompetent hosts in recent years. Although the lungs and central nervous system constitute the most common sites of infection, cryptococcal osteomyelitis remains exceptionally rare and is typically associated with disseminated disease in immunodeficient patients. Herein, we present a rare case of isolated tibial cryptococcal osteomyelitis in an immunocompetent patient.<h4>Case presentation</h4>We report a case of a 64-year-old female who presented with pain, swelling, and increased","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:36:56.862Z","creation":"2026-05-02T03:07:55.583Z"},"accession":"S-EPMC12465621","cross_references":{"pubmed":["41013340"],"doi":["10.1186/s12879-025-11451-y"]}}