{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Storms CR"],"funding":["American Heart Association","NHLBI NIH HHS","NIH HHS"],"pagination":["398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Background</h4>Ultrasound-measured brachial artery reactive hyperemia (RH) is independently predictive of hospital mortality in critically ill patients with sepsis. Its association with mortality is uncertain in critically ill patients in general.<h4>Methods</h4>This was a combined case-control and prospective cohort study. Ultrasound was used to measure brachial artery reactive hyperemia in 150 critically ill patients at a single academic medical center and in 44 control subjects without acute illness. Measurements were compared in cases versus controls, septic vs. non-septic critically ill patients, and hospital survivors vs. non-survivors. Follow-up measurements were obtained 3-5 days later in a sub-sample of patients.<h4>Results</h4>RH was calculated as the percent change in pre- vs. post-ischemic brachial artery velocity-time integral measured by Doppler ultrasound. RH was impaired in critically ill compared to control subjects (194 [179-210] vs. 369 [314-433]%, p < 0.001; results expressed as mean [95% confidence interval]) but similar in septic compared to non-septic patients (196 [177-217] vs. 199 [170-233], p = 0.88). RH was significantly lower in hospital non-survivors compared to survivors (144 [120-173] vs. 204 [187-222], p = 0.003). Multivariable analysis showed that the difference between survivors and non-survivors was not confounded by age or comorbidities (odds ratio for hospital death = 0.26 per log unit rise in RH, 95% confidence interval = 0.08-0.83, p = 0.02). The magnitude of RH improved over 3-5 days in hospital survivors (n = 63, 204 [180-232] vs. 239 [208-275], p = 0.02), but did not change in non-survivors (n = 11, 133 [107-165] vs. 128 [75-220].<h4>Conclusions</h4>Reactive hyperemia of the brachial artery is impaired in undifferentiated critically ill patients, lower in non-survivors compared to survivors, and independently associated with hospital mortality. Brachial artery reactive hyperemia improves significantly over time in survivors but not in non-survivors."],"journal":["Critical care (London, England)"],"pubmed_title":["Ultrasound-measured brachial artery reactive hyperemia in critically ill patients: an observational study."],"pmcid":["PMC12465633"],"funding_grant_id":["R01 HL 160723","3CRP17110114","R01 HL160723"],"pubmed_authors":["Clark H","Dony C","Rovitelli AMK","Malnoske M","Zhang J","Maeda T","Bice T","Pietropaoli AP","Kumar N","Storms CR","Fe AZ","Levy E","Illipparambil LC","Wexler O","Shultz R"],"additional_accession":[]},"is_claimable":false,"name":"Ultrasound-measured brachial artery reactive hyperemia in critically ill patients: an observational study.","description":"<h4>Background</h4>Ultrasound-measured brachial artery reactive hyperemia (RH) is independently predictive of hospital mortality in critically ill patients with sepsis. Its association with mortality is uncertain in critically ill patients in general.<h4>Methods</h4>This was a combined case-control and prospective cohort study. Ultrasound was used to measure brachial artery reactive hyperemia in 150 critically ill patients at a single academic medical center and in 44 control subjects without acute illness. Measurements were compared in cases versus controls, septic vs. non-septic critically ill patients, and hospital survivors vs. non-survivors. Follow-up measurements were obtained 3-5 days later in a sub-sample of patients.<h4>Results</h4>RH was calculated as the percent change in pre- vs. post-ischemic brachial artery velocity-time integral measured by Doppler ultrasound. RH was impaired in critically ill compared to control subjects (194 [179-210] vs. 369 [314-433]%, p < 0.001; results expressed as mean [95% confidence interval]) but similar in septic compared to non-septic patients (196 [177-217] vs. 199 [170-233], p = 0.88). RH was significantly lower in hospital non-survivors compared to survivors (144 [120-173] vs. 204 [187-222], p = 0.003). Multivariable analysis showed that the difference between survivors and non-survivors was not confounded by age or comorbidities (odds ratio for hospital death = 0.26 per log unit rise in RH, 95% confidence interval = 0.08-0.83, p = 0.02). The magnitude of RH improved over 3-5 days in hospital survivors (n = 63, 204 [180-232] vs. 239 [208-275], p = 0.02), but did not change in non-survivors (n = 11, 133 [107-165] vs. 128 [75-220].<h4>Conclusions</h4>Reactive hyperemia of the brachial artery is impaired in undifferentiated critically ill patients, lower in non-survivors compared to survivors, and independently associated with hospital mortality. Brachial artery reactive hyperemia improves significantly over time in survivors but not in non-survivors.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:13:10.447Z","creation":"2026-05-01T03:10:39.596Z"},"accession":"S-EPMC12465633","cross_references":{"pubmed":["40999434"],"doi":["10.1186/s13054-025-05646-7"]}}