{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alminana C"],"funding":["Universitätsspital Zürich","Universität Zürich","EMDO Stiftung"],"pagination":["62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465895"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(1)"],"pubmed_abstract":["<h4>Background</h4>Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted reproductive technologies (ART) are considered as a treatment option. However, the impact of E on oocyte quality, its potential to be fertilized as well as pregnancy rates, is still under debate and with very few molecular clues explaining the clinical data. Alterations in protein-coding RNAs in cumulus cells (CCs), cells surrounding the oocytes and contributing to oocyte maturation, have been reported in E patients. But there is a lack of information regarding microRNAs (miRNAs), which control protein translation. Thus, we aimed: (1) to identify altered miR"],"journal":["Biological research"],"pubmed_title":["Endometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization."],"pmcid":["PMC12465895"],"funding_grant_id":["URPP Human Reproduction Reloaded | H2R","FAN grant 2023","Clinic Funds","EMDO Stiftung"],"pubmed_authors":["Leeners B","Bauersachs S","Cervantes N","Ulbrich SE","Alminana C","Velasco A","Makieva S","Spalinger MR","Xie M","Saenz-de-Juano MD"],"additional_accession":[]},"is_claimable":false,"name":"Endometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization.","description":"<h4>Background</h4>Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted reproductive technologies (ART) are considered as a treatment option. However, the impact of E on oocyte quality, its potential to be fertilized as well as pregnancy rates, is still under debate and with very few molecular clues explaining the clinical data. Alterations in protein-coding RNAs in cumulus cells (CCs), cells surrounding the oocytes and contributing to oocyte maturation, have been reported in E patients. But there is a lack of information regarding microRNAs (miRNAs), which control protein translation. Thus, we aimed: (1) to identify altered miR","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:42:41.994Z","creation":"2026-05-02T03:08:27.002Z"},"accession":"S-EPMC12465895","cross_references":{"pubmed":["41013698"],"doi":["10.1186/s40659-025-00641-2"]}}