biostudies-literatureAlminana CUniversitätsspital ZürichUniversität ZürichEMDO Stiftung62https://www.ebi.ac.uk/biostudies/studies/S-EPMC12465895biostudies-literatureUnknown58(1)<h4>Background</h4>Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted reproductive technologies (ART) are considered as a treatment option. However, the impact of E on oocyte quality, its potential to be fertilized as well as pregnancy rates, is still under debate and with very few molecular clues explaining the clinical data. Alterations in protein-coding RNAs in cumulus cells (CCs), cells surrounding the oocytes and contributing to oocyte maturation, have been reported in E patients. But there is a lack of information regarding microRNAs (miRNAs), which control protein translation. Thus, we aimed: (1) to identify altered miRBiological researchEndometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization.PMC12465895URPP Human Reproduction Reloaded | H2RFAN grant 2023Clinic FundsEMDO StiftungLeeners BBauersachs SCervantes NUlbrich SEAlminana CVelasco AMakieva SSpalinger MRXie MSaenz-de-Juano MDfalseEndometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization.<h4>Background</h4>Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted reproductive technologies (ART) are considered as a treatment option. However, the impact of E on oocyte quality, its potential to be fertilized as well as pregnancy rates, is still under debate and with very few molecular clues explaining the clinical data. Alterations in protein-coding RNAs in cumulus cells (CCs), cells surrounding the oocytes and contributing to oocyte maturation, have been reported in E patients. But there is a lack of information regarding microRNAs (miRNAs), which control protein translation. Thus, we aimed: (1) to identify altered miR2025-01-01T00:00:00Z2025 Sep2026-06-03T21:42:41.994Z2026-05-02T03:08:27.002ZS-EPMC124658954101369810.1186/s40659-025-00641-2