{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu C"],"funding":["Natural Science Foundation of Zhejiang Province","Senior Talent Start-up Funds of Jiangsu University","China Postdoctoral Science Foundation","National Natural Science Foundation of China","National Key Research and Development Program of China","Natural Science Foundation of Jiangsu Province"],"pagination":["852"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["<b>Background:</b> The emergence and spread of the tigecycline resistance gene <i>tet</i>(A)-v1 in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses significant public health challenges. However, the prevalence of <i>tet</i>(A)-v1-positive CRKP, especially in pediatric patients, remains poorly understood. This study aims to address the gap by performing an in-depth analysis of isolates collected from a children's hospital in China. <b>Methods</b>: A 4-year retrospective study was conducted in the children's hospital in Suzhou, China. Non-duplicated specimens were obtained from pediatric patients, and antimicrobial susceptibility profiles were assessed. Whole-genome sequencing and bioinformatics analyses were conducted to characterize the genetic background, antimicrobial resis"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Molecular Epidemiology of &lt;i&gt;tet&lt;/i&gt;(A)-v1-Positive Carbapenem-Resistant &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; in Pediatric Patients in a Chinese Hospital."],"pmcid":["PMC12466384"],"funding_grant_id":["2023M731375","LMS25C010002","2024YFC2310905","5501280007","32300156","BK20220493"],"pubmed_authors":["Zhou M","Zhang G","Jiang J","Li C","Xu C","Zeng X","Huang L","Dong N","Li X","Liu Y","Li Y","Yang Y","You J","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Epidemiology of &lt;i&gt;tet&lt;/i&gt;(A)-v1-Positive Carbapenem-Resistant &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; in Pediatric Patients in a Chinese Hospital.","description":"<b>Background:</b> The emergence and spread of the tigecycline resistance gene <i>tet</i>(A)-v1 in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses significant public health challenges. However, the prevalence of <i>tet</i>(A)-v1-positive CRKP, especially in pediatric patients, remains poorly understood. This study aims to address the gap by performing an in-depth analysis of isolates collected from a children's hospital in China. <b>Methods</b>: A 4-year retrospective study was conducted in the children's hospital in Suzhou, China. Non-duplicated specimens were obtained from pediatric patients, and antimicrobial susceptibility profiles were assessed. Whole-genome sequencing and bioinformatics analyses were conducted to characterize the genetic background, antimicrobial resis","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-02T03:16:20.607Z","creation":"2026-05-02T03:09:32.527Z"},"accession":"S-EPMC12466384","cross_references":{"pubmed":["41009831"],"doi":["10.3390/antibiotics14090852"]}}