biostudies-literatureXu CNatural Science Foundation of Zhejiang ProvinceSenior Talent Start-up Funds of Jiangsu UniversityChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNatural Science Foundation of Jiangsu Province852https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466384biostudies-literatureUnknown14(9)<b>Background:</b> The emergence and spread of the tigecycline resistance gene <i>tet</i>(A)-v1 in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses significant public health challenges. However, the prevalence of <i>tet</i>(A)-v1-positive CRKP, especially in pediatric patients, remains poorly understood. This study aims to address the gap by performing an in-depth analysis of isolates collected from a children's hospital in China. <b>Methods</b>: A 4-year retrospective study was conducted in the children's hospital in Suzhou, China. Non-duplicated specimens were obtained from pediatric patients, and antimicrobial susceptibility profiles were assessed. Whole-genome sequencing and bioinformatics analyses were conducted to characterize the genetic background, antimicrobial resisAntibiotics (Basel, Switzerland)Molecular Epidemiology of <i>tet</i>(A)-v1-Positive Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in Pediatric Patients in a Chinese Hospital.PMC124663842023M731375LMS25C0100022024YFC2310905550128000732300156BK20220493Zhou MZhang GJiang JLi CXu CZeng XHuang LDong NLi XLiu YLi YYang YYou JChen SfalseMolecular Epidemiology of <i>tet</i>(A)-v1-Positive Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in Pediatric Patients in a Chinese Hospital.<b>Background:</b> The emergence and spread of the tigecycline resistance gene <i>tet</i>(A)-v1 in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses significant public health challenges. However, the prevalence of <i>tet</i>(A)-v1-positive CRKP, especially in pediatric patients, remains poorly understood. This study aims to address the gap by performing an in-depth analysis of isolates collected from a children's hospital in China. <b>Methods</b>: A 4-year retrospective study was conducted in the children's hospital in Suzhou, China. Non-duplicated specimens were obtained from pediatric patients, and antimicrobial susceptibility profiles were assessed. Whole-genome sequencing and bioinformatics analyses were conducted to characterize the genetic background, antimicrobial resis2025-01-01T00:00:00Z2025 Aug2026-05-02T03:16:20.607Z2026-05-02T03:09:32.527ZS-EPMC124663844100983110.3390/antibiotics14090852