{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rink M"],"funding":["German Center for Infection Research"],"pagination":["853"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466468"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["<h4>Background/objectives</h4>While antibiotic prophylaxis is crucial for preventing infections, its impact on the development of antibiotic-resistant infections and clinical outcomes remains underexplored. We aimed to systematically assess the impact of medical and surgical antibiotic prophylaxis (SAP) on the development of antibiotic-resistant infections, clinical outcomes, and costs.<h4>Methods</h4>A systematic review and meta-analysis of the effect of antibiotic prophylaxis on antibiotic-resistant infections, mortality, length of hospital stay, and/or costs was conducted in hemato-oncological or surgical patient populations. Pooled estimates of the relative risk (RR) or weighted mean difference (WMD) were derived using random-effect meta-analysis.<h4>Results</h4>Of 10,409 screened stud"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["The Impact of Antibiotic Prophylaxis on Antibiotic Resistance, Clinical Outcomes, and Costs in Adult Hemato-Oncological and Surgical Patients: A Systematic Review and Meta-Analysis."],"pmcid":["PMC12466468"],"funding_grant_id":["TTU 08.707"],"pubmed_authors":["Bitzer M","Nikolai LA","Tacconelli E","Rink M","Gopel S","Gladstone BP"],"additional_accession":[]},"is_claimable":false,"name":"The Impact of Antibiotic Prophylaxis on Antibiotic Resistance, Clinical Outcomes, and Costs in Adult Hemato-Oncological and Surgical Patients: A Systematic Review and Meta-Analysis.","description":"<h4>Background/objectives</h4>While antibiotic prophylaxis is crucial for preventing infections, its impact on the development of antibiotic-resistant infections and clinical outcomes remains underexplored. We aimed to systematically assess the impact of medical and surgical antibiotic prophylaxis (SAP) on the development of antibiotic-resistant infections, clinical outcomes, and costs.<h4>Methods</h4>A systematic review and meta-analysis of the effect of antibiotic prophylaxis on antibiotic-resistant infections, mortality, length of hospital stay, and/or costs was conducted in hemato-oncological or surgical patient populations. Pooled estimates of the relative risk (RR) or weighted mean difference (WMD) were derived using random-effect meta-analysis.<h4>Results</h4>Of 10,409 screened stud","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-02T03:16:24.664Z","creation":"2026-05-02T03:09:33.211Z"},"accession":"S-EPMC12466468","cross_references":{"pubmed":["41009832"],"doi":["10.3390/antibiotics14090853"]}}