{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DelNero P"],"funding":["American Cancer Society","NCATS NIH HHS","Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","/Arkansas Insurance Department/Arkansas Healthcare Transparency Initiative Collaboration","NIH HHS","Arkansas Biosciences Institute"],"pagination":["e70045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(3)"],"pubmed_abstract":["<h4>Purpose</h4>We examined whether living in persistent poverty census tracts was associated with disparities in colorectal cancer (CRC) survival and whether the association varied between urban and rural settings.<h4>Methods</h4>Using 2013-2019 state-wide cancer registry and 2013-2021 death records data, CRC patients were classified by tract-level persistent poverty and rural/urban status. Overall and CRC-specific survival were compared using Kaplan-Meier estimation and log-rank tests. Adjusted analyses were conducted using Cox proportional hazard and Fine-Gray competing risk models.<h4>Findings</h4>During the study period, 558 (53%) of 1055 CRC patients died in persistent poverty tracts versus 3117 (45%) of 6938 patients in nonpersistent poverty tracts. Of the 3675 deaths, 2269 (61.7%) were from CRC-specific causes. In unadjusted analysis, CRC patients in persistent poverty areas had a higher risk of all-cause (HR, 95%CI: 1.28, 1.17-1.40) and CRC-specific (HR, 95% CI: 1.17, 1.04-1.31) mortality. After covariates adjustment, the relationship between persistent poverty and all-cause mortality (HR, 95% CI: 1.17, 1.06-1.29) and non-CRC-specific mortality (HR, 95% CI: 1.34, 1.15-1.57) remained significant, but CRC-specific mortality did not. In subgroup analyses, persistent poverty was associated with increased overall mortality among urban tracts (HR, 95% CI: 1.22, 1.08-1.38), but not rural tracts.<h4>Conclusions</h4>After covariates adjustment, CRC patients in persistent poverty tracts are more likely to die of all causes and non-CRC causes but not CRC-specific causes than those in nonpersistent poverty areas, suggesting that differences in CRC-specific deaths may be partly attributed to demographics, geography, tumor characteristics, and treatment."],"journal":["The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association"],"pubmed_title":["Colorectal cancer survival disparities in persistent poverty areas."],"pmcid":["PMC12466537"],"funding_grant_id":["RSGI-23-1039245-01-HOPS","UM1 TR004909","UL1 TR003107"],"pubmed_authors":["Schootman M","Laryea J","Li C","Saini M","Peng C","DelNero P","Hallgren E"],"additional_accession":[]},"is_claimable":false,"name":"Colorectal cancer survival disparities in persistent poverty areas.","description":"<h4>Purpose</h4>We examined whether living in persistent poverty census tracts was associated with disparities in colorectal cancer (CRC) survival and whether the association varied between urban and rural settings.<h4>Methods</h4>Using 2013-2019 state-wide cancer registry and 2013-2021 death records data, CRC patients were classified by tract-level persistent poverty and rural/urban status. Overall and CRC-specific survival were compared using Kaplan-Meier estimation and log-rank tests. Adjusted analyses were conducted using Cox proportional hazard and Fine-Gray competing risk models.<h4>Findings</h4>During the study period, 558 (53%) of 1055 CRC patients died in persistent poverty tracts versus 3117 (45%) of 6938 patients in nonpersistent poverty tracts. Of the 3675 deaths, 2269 (61.7%) were from CRC-specific causes. In unadjusted analysis, CRC patients in persistent poverty areas had a higher risk of all-cause (HR, 95%CI: 1.28, 1.17-1.40) and CRC-specific (HR, 95% CI: 1.17, 1.04-1.31) mortality. After covariates adjustment, the relationship between persistent poverty and all-cause mortality (HR, 95% CI: 1.17, 1.06-1.29) and non-CRC-specific mortality (HR, 95% CI: 1.34, 1.15-1.57) remained significant, but CRC-specific mortality did not. In subgroup analyses, persistent poverty was associated with increased overall mortality among urban tracts (HR, 95% CI: 1.22, 1.08-1.38), but not rural tracts.<h4>Conclusions</h4>After covariates adjustment, CRC patients in persistent poverty tracts are more likely to die of all causes and non-CRC causes but not CRC-specific causes than those in nonpersistent poverty areas, suggesting that differences in CRC-specific deaths may be partly attributed to demographics, geography, tumor characteristics, and treatment.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T21:13:19.91Z","creation":"2026-05-01T03:10:42.19Z"},"accession":"S-EPMC12466537","cross_references":{"pubmed":["40629554"],"doi":["10.1111/jrh.70045"]}}