{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yang Y"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pubmed_abstract":["Lung cancer is a highly heterogeneous disease primarily driven by tobacco smoking. About 20% of lung cancers occur among patients who have never smoked (LCINS) with differences in patient ancestry, sex, tumor histology, and clinical features. Our understanding of chromosomal instability in lung cancer, especially LCINS, is still limited. Here, we perform a comprehensive study of 182,429 somatic structural variations (SVs) detected in 1,209 whole-genome sequenced lung cancers, of which 864 LCINS. SVs are more abundant in tumors from patients who have smoked (LCSS); however, they are more complex and play more important roles in tumorigenesis in LCINS. <i>EGFR</i> mutations and <i>KRAS</i> mutations profoundly and independently shape the SV landscape. <i>EGFR</i>-mutant tumors have higher SV"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.09.09.25335109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466783"],"repository":["biostudies-literature"],"pubmed_title":["Panorama of Chromosomal Instability in Lung Cancer."],"pmcid":["PMC12466783"],"funding_grant_id":["ZIA CP101231","R01 CA269977"],"pubmed_authors":["Santamaria JM","Kontic M","Christiani DC","Holcatova I","Hoang PH","McElderry JP","Rothman N","Chen CY","Edell ES","Wong MP","Homer R","Yendamuri SS","Chanock SJ","Brennan P","Sharma S","Yang L","Zhong X","Swiatkowska B","Khandekar A","Hofman P","Wirth C","Yang SR","Leung KC","Consonni D","Yang Y","Landi MT","Janout V","Lan Q","Pesatori AC","Zaridze D","Sang J","Schabath MB","Diaz-Gay M","Mukeria A","Joubert P","Manczuk M","Ognjanovic S","Zhao W","Mates D","Baine MK","Miraftab M","Sholl LM","Wedge DC","Savic M","Gaborieau V","Hsiung CA","Nowak MA","Travis WD","Alexandrov LB","Jones KM","Tran TV","Zhu B","Lee OW","Zhang T","Hartman C","Phillips W","Leduc C","Lissowska J","Shangina O","Shi J","Saha M","Rothberg BEG","Bosse Y","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"Panorama of Chromosomal Instability in Lung Cancer.","description":"Lung cancer is a highly heterogeneous disease primarily driven by tobacco smoking. About 20% of lung cancers occur among patients who have never smoked (LCINS) with differences in patient ancestry, sex, tumor histology, and clinical features. Our understanding of chromosomal instability in lung cancer, especially LCINS, is still limited. Here, we perform a comprehensive study of 182,429 somatic structural variations (SVs) detected in 1,209 whole-genome sequenced lung cancers, of which 864 LCINS. SVs are more abundant in tumors from patients who have smoked (LCSS); however, they are more complex and play more important roles in tumorigenesis in LCINS. <i>EGFR</i> mutations and <i>KRAS</i> mutations profoundly and independently shape the SV landscape. <i>EGFR</i>-mutant tumors have higher SV","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-07T03:18:37.269Z","creation":"2026-05-07T03:12:20.491Z"},"accession":"S-EPMC12466783","cross_references":{"pubmed":["41018008"],"doi":["10.1101/2025.09.09.25335109"]}}