{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye W"],"funding":["Jun Qiang","Kai Liu"],"pagination":["1112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466869"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["The utilization of saline-alkali water resources presents a promising approach for freshwater aquaculture. Red tilapia (<i>Oreochromis</i> spp.) exhibits moderate salinity tolerance, but its adaptation mechanism to alkaline conditions remains poorly understood. In the current study, five alkaline carbonate concentrations in a 60-day chronic stress experiment on red tilapia were evaluated. The experimental design included a control group (CA0, 0 mmol/L) and three treatment groups (CA10, 20 mmol/L; CA30, 30 mmol/L; and CA40 40 mmol/L). The results indicated that at alkaline carbonate concentrations exceeding 20 mmol/L, the gill filaments exhibited curling and deformation, the hepatocytes displayed migration, and tissue damage increased significantly. The gill's antioxidant capacity initially"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Physiological and Transcriptome Analyses Offer Insights into Revealing the Mechanisms of Red Tilapia (&lt;i&gt;Oreochromis&lt;/i&gt; spp.) in Response to Carbonate Alkalinity Stress."],"pmcid":["PMC12466869"],"funding_grant_id":["2023ZD04065","2022YFE0139600","NO.2023TD11"],"pubmed_authors":["Hua J","Xu D","Ye W","Wang W","Qiang J"],"additional_accession":[]},"is_claimable":false,"name":"Physiological and Transcriptome Analyses Offer Insights into Revealing the Mechanisms of Red Tilapia (&lt;i&gt;Oreochromis&lt;/i&gt; spp.) in Response to Carbonate Alkalinity Stress.","description":"The utilization of saline-alkali water resources presents a promising approach for freshwater aquaculture. Red tilapia (<i>Oreochromis</i> spp.) exhibits moderate salinity tolerance, but its adaptation mechanism to alkaline conditions remains poorly understood. In the current study, five alkaline carbonate concentrations in a 60-day chronic stress experiment on red tilapia were evaluated. The experimental design included a control group (CA0, 0 mmol/L) and three treatment groups (CA10, 20 mmol/L; CA30, 30 mmol/L; and CA40 40 mmol/L). The results indicated that at alkaline carbonate concentrations exceeding 20 mmol/L, the gill filaments exhibited curling and deformation, the hepatocytes displayed migration, and tissue damage increased significantly. The gill's antioxidant capacity initially","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:10:20.939Z","creation":"2026-05-02T03:07:47.709Z"},"accession":"S-EPMC12466869","cross_references":{"pubmed":["41009016"],"doi":["10.3390/antiox14091112"]}}