biostudies-literatureUnknown15(42)Samanta KKIn this research work, the aqueous root extract of <i>Glycyrrhiza glabra</i> (<i>G. glabra</i>) was used to synthesize phytoconstituent-coated zinc oxide nanoparticles (ZnONPs) for the first time. The plant extract served as a reducing and coating/stabilizing agent. The alteration in the physicochemical properties and biomedical potential of the synthesized ZnONPs with an increase in the volume of <i>G. glabra</i> extract was investigated, making this study different from others. X-ray diffraction (XRD) analysis confirms that the average crystallite size of the nanoparticles decreased with an increase in the plant extract volume. Field-emission scanning electron microscopy (FESEM) analysis confirmed the formation of uniform spherical particles for all three samples, while energy-dispersiveRSC advances35598-35616https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466927biostudies-literatureNature-inspired ZnO nanoparticles: unlocking the biomedical potential of &lt;i&gt;Glycyrrhiza glabra&lt;/i&gt;-mediated green synthesis through &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in silico&lt;/i&gt; approaches.PMC12466927Hait PBhunia BMamgain HPManna SBasu SSamanta KKKumar MPandey JKfalseNature-inspired ZnO nanoparticles: unlocking the biomedical potential of &lt;i&gt;Glycyrrhiza glabra&lt;/i&gt;-mediated green synthesis through &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in silico&lt;/i&gt; approaches.In this research work, the aqueous root extract of <i>Glycyrrhiza glabra</i> (<i>G. glabra</i>) was used to synthesize phytoconstituent-coated zinc oxide nanoparticles (ZnONPs) for the first time. The plant extract served as a reducing and coating/stabilizing agent. The alteration in the physicochemical properties and biomedical potential of the synthesized ZnONPs with an increase in the volume of <i>G. glabra</i> extract was investigated, making this study different from others. X-ray diffraction (XRD) analysis confirms that the average crystallite size of the nanoparticles decreased with an increase in the plant extract volume. Field-emission scanning electron microscopy (FESEM) analysis confirmed the formation of uniform spherical particles for all three samples, while energy-dispersive2025-01-01T00:00:00Z2025 Sep2026-06-03T23:16:04.227Z2026-05-02T03:11:51.781ZS-EPMC124669274101982010.1039/d5ra05670e