{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(42)"],"submitter":["Long B"],"pubmed_abstract":["Enantiopure <i>syn</i>-β-amino-α-hydroxy acids have been synthesized from α-amino acids in a multi-step procedure that exhibits a high level of stereoselectivity and good overall yields. A stepwise oxidation of the terminal olefin to a carboxylic acid delivered an essentially quantitative yield <i>via</i> a cleaner process relative to the conventional one-pot oxidation. The practical value of this transformation has been demonstrated in the formal synthesis of l-TFB-TBOA and (S)-vigabatrin."],"journal":["RSC advances"],"pagination":["35635-35641"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466934"],"repository":["biostudies-literature"],"pubmed_title":["A practical synthesis of enantiopure &lt;i&gt;syn&lt;/i&gt;-β-amino-α-hydroxy acids from α-amino acids with application in the formal syntheses of l-TFB-TBOA and (S)-vigabatrin."],"pmcid":["PMC12466934"],"pubmed_authors":["Wu Z","Chen X","Jiang M","Long B","Guo P","Zhang P","Shang S"],"additional_accession":[]},"is_claimable":false,"name":"A practical synthesis of enantiopure &lt;i&gt;syn&lt;/i&gt;-β-amino-α-hydroxy acids from α-amino acids with application in the formal syntheses of l-TFB-TBOA and (S)-vigabatrin.","description":"Enantiopure <i>syn</i>-β-amino-α-hydroxy acids have been synthesized from α-amino acids in a multi-step procedure that exhibits a high level of stereoselectivity and good overall yields. A stepwise oxidation of the terminal olefin to a carboxylic acid delivered an essentially quantitative yield <i>via</i> a cleaner process relative to the conventional one-pot oxidation. The practical value of this transformation has been demonstrated in the formal synthesis of l-TFB-TBOA and (S)-vigabatrin.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T16:49:21.926Z","creation":"2026-05-13T14:24:30.671Z"},"accession":"S-EPMC12466934","cross_references":{"pubmed":["41019804"],"doi":["10.1039/d5ra05586e"]}}