biostudies-literatureUnknown15(42)Long BEnantiopure <i>syn</i>-β-amino-α-hydroxy acids have been synthesized from α-amino acids in a multi-step procedure that exhibits a high level of stereoselectivity and good overall yields. A stepwise oxidation of the terminal olefin to a carboxylic acid delivered an essentially quantitative yield <i>via</i> a cleaner process relative to the conventional one-pot oxidation. The practical value of this transformation has been demonstrated in the formal synthesis of l-TFB-TBOA and (S)-vigabatrin.RSC advances35635-35641https://www.ebi.ac.uk/biostudies/studies/S-EPMC12466934biostudies-literatureA practical synthesis of enantiopure &lt;i&gt;syn&lt;/i&gt;-β-amino-α-hydroxy acids from α-amino acids with application in the formal syntheses of l-TFB-TBOA and (S)-vigabatrin.PMC12466934Wu ZChen XJiang MLong BGuo PZhang PShang SfalseA practical synthesis of enantiopure &lt;i&gt;syn&lt;/i&gt;-β-amino-α-hydroxy acids from α-amino acids with application in the formal syntheses of l-TFB-TBOA and (S)-vigabatrin.Enantiopure <i>syn</i>-β-amino-α-hydroxy acids have been synthesized from α-amino acids in a multi-step procedure that exhibits a high level of stereoselectivity and good overall yields. A stepwise oxidation of the terminal olefin to a carboxylic acid delivered an essentially quantitative yield <i>via</i> a cleaner process relative to the conventional one-pot oxidation. The practical value of this transformation has been demonstrated in the formal synthesis of l-TFB-TBOA and (S)-vigabatrin.2025-01-01T00:00:00Z2025 Sep2026-06-04T16:49:21.926Z2026-05-13T14:24:30.671ZS-EPMC124669344101980410.1039/d5ra05586e