{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu W"],"funding":["Natural Science Foundation of Tianjin Science and Technology Correspondent","National Natural Science Foundation of China"],"pagination":["1111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12467003"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Cytochrome P450 monooxygenases (P450s) are one of the most widespread enzyme superfamilies in the biological world. In insects, P450 proteins play a crucial role in the synthesis of endogenous substances and the metabolism of xenobiotics. To date, extensive research has been conducted on P450 gene-mediated detoxification and metabolism across multiple insect species. While Chironomidae species-dominant benthic organisms inhabiting diverse ecological niches and playing critical ecological roles-remain largely uncharacterized in terms of P450 protein annotation, with the exception of a single study on <i>Propsilocerus akamusi</i>. In this study, we expanded the annotation scope by identifying the P450 protein genes in eight additional Chironomidae species. A total of 577 P450 protein genes w"],"journal":["Biology"],"pubmed_title":["Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species."],"pmcid":["PMC12467003"],"funding_grant_id":["32370489, 32170473","23KPHDRC00240, 22KPXMRC00070"],"pubmed_authors":["Zhou A","Shao Z","Zhang Y","Nie J","Nie Z","Yan C","Liu C","Wang Y","Gao S","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species.","description":"Cytochrome P450 monooxygenases (P450s) are one of the most widespread enzyme superfamilies in the biological world. In insects, P450 proteins play a crucial role in the synthesis of endogenous substances and the metabolism of xenobiotics. To date, extensive research has been conducted on P450 gene-mediated detoxification and metabolism across multiple insect species. While Chironomidae species-dominant benthic organisms inhabiting diverse ecological niches and playing critical ecological roles-remain largely uncharacterized in terms of P450 protein annotation, with the exception of a single study on <i>Propsilocerus akamusi</i>. In this study, we expanded the annotation scope by identifying the P450 protein genes in eight additional Chironomidae species. A total of 577 P450 protein genes w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-02T03:20:49.52Z","creation":"2026-05-02T03:12:02.382Z"},"accession":"S-EPMC12467003","cross_references":{"pubmed":["41007257"],"doi":["10.3390/biology14091111"]}}