biostudies-literatureUnknown13(9)Ain QT<b>Background:</b> Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, improves outcomes in heart failure (HF) patients, yet inter-individual variability in response remains unclear. Genetic variants in Brain-Derived Neurotrophic Factor <i>BDNF</i> (rs6265) and ATPase Sarcoplasmic/Endoplasmic Reticulum Ca²⁺ Transporting 2 ATP2A2 (rs1860561) may influence the treatment efficacy. <b>Objective:</b> To assess the association of <i>BDNF</i> and <i>ATP2A2</i> polymorphisms with the response to low-dose empagliflozin (10 mg) in Pakistani patients with heart failure and a reduced ejection fraction (HFrEF). <b>Methods:</b> In this prospective study, 120 HF patients with an ejection fraction of 25-45% who had been on stable standard heart failure therapy for at least 3 montBiomedicines2095https://www.ebi.ac.uk/biostudies/studies/S-EPMC12467674biostudies-literaturePersonalized Response to Empagliflozin in Heart Failure: Association of BDNF and ATP2A2 Variants in a South Asian Cohort.PMC12467674Hasan AKhan AAAhmed SAzam FUsman MAin QTIjaz UAhmed RAli MShaheen AAhmed MfalsePersonalized Response to Empagliflozin in Heart Failure: Association of BDNF and ATP2A2 Variants in a South Asian Cohort.<b>Background:</b> Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, improves outcomes in heart failure (HF) patients, yet inter-individual variability in response remains unclear. Genetic variants in Brain-Derived Neurotrophic Factor <i>BDNF</i> (rs6265) and ATPase Sarcoplasmic/Endoplasmic Reticulum Ca²⁺ Transporting 2 ATP2A2 (rs1860561) may influence the treatment efficacy. <b>Objective:</b> To assess the association of <i>BDNF</i> and <i>ATP2A2</i> polymorphisms with the response to low-dose empagliflozin (10 mg) in Pakistani patients with heart failure and a reduced ejection fraction (HFrEF). <b>Methods:</b> In this prospective study, 120 HF patients with an ejection fraction of 25-45% who had been on stable standard heart failure therapy for at least 3 mont2025-01-01T00:00:00Z2025 Aug2026-06-30T03:24:08.686Z2026-06-30T03:16:37.13ZS-EPMC124676744100765810.3390/biomedicines13092095