{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao L"],"funding":["National Natural Science Foundation of China"],"pagination":["1323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12467997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(9)"],"pubmed_abstract":["Aminoacyl-tRNA synthetases (AARSs), traditionally recognized for their essential role in protein synthesis, are now emerging as critical players in cancer pathogenesis through translation-independent functions. Lactate-derived lactylation, a post-translational modification, plays an increasingly important role in tumorigenesis in the context of high levels of lactate in tumor cells due to the Warburg effect. Current research has highlighted AARS1/2 as lactate sensors and lactyltransferases that catalyze global lysine lactylation in cancer cells and promote cancer proliferation, providing a new perspective for cancer therapy. This review synthesizes the canonical and non-canonical functions of AARS1/2, with a particular focus on their lactylation-related mechanisms; details how lactylation "],"journal":["Biomolecules"],"pubmed_title":["AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis."],"pmcid":["PMC12467997"],"funding_grant_id":["82170966"],"pubmed_authors":["Guo J","Gao L","Jia R"],"additional_accession":[]},"is_claimable":false,"name":"AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis.","description":"Aminoacyl-tRNA synthetases (AARSs), traditionally recognized for their essential role in protein synthesis, are now emerging as critical players in cancer pathogenesis through translation-independent functions. Lactate-derived lactylation, a post-translational modification, plays an increasingly important role in tumorigenesis in the context of high levels of lactate in tumor cells due to the Warburg effect. Current research has highlighted AARS1/2 as lactate sensors and lactyltransferases that catalyze global lysine lactylation in cancer cells and promote cancer proliferation, providing a new perspective for cancer therapy. This review synthesizes the canonical and non-canonical functions of AARS1/2, with a particular focus on their lactylation-related mechanisms; details how lactylation ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:09:32.207Z","creation":"2026-05-02T03:07:36.926Z"},"accession":"S-EPMC12467997","cross_references":{"pubmed":["41008630"],"doi":["10.3390/biom15091323"]}}