{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rojo-Pardillo M"],"funding":["Héger-Masson Foundation","David et Alice Van Buuren Foundation","Rose et Jean Hoguet Foundation","Fund for Scientific Research - FRIA grant","King Baudouin Foundation - Fund Doctor J.P. Naets","Fund for Scientific Research - Research credit","Jaumotte-Demoulin Foundation"],"pagination":["1465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(18)"],"pubmed_abstract":["Beyond well-known genetic drivers, microRNA dysregulation has emerged as a key contributor to thyroid tumorigenesis. Central to this process is <i>Dicer1</i>, a ribonuclease essential for microRNA maturation, whose expression is often reduced in papillary thyroid carcinoma (PTC). Evidence from previous studies suggest <i>Dicer1</i> functions as a context-dependent haplo-insufficient tumor suppressor gene: partial loss may promote tumor development, whereas complete loss may disrupt essential cellular functions, causing cell death and tumor suppression. However, the effects of partial or complete <i>Dicer1</i> loss in thyroid cancer remain unclear. To explore this, we genetically inactivated one (heterozygous) or both (homozygous) <i>Dicer1</i> alleles specifically in thyroid follicular cel"],"journal":["Cells"],"pubmed_title":["&lt;i&gt;Dicer1&lt;/i&gt; Depletion Leads to DNA Damage Accumulation and Cell Death in a RET/PTC3 Papillary Thyroid Cancer Mouse Model, Thereby Inhibiting Tumor Progression."],"pmcid":["PMC12468101"],"funding_grant_id":["CDR J.0150.25","FC36079","CDR J.0123.23","2023-J1813300-233020","2025-J1813300-0025101"],"pubmed_authors":["Kero J","Rojo-Pardillo M","Robaye B","Augenlicht A","Maenhaut C","Dom G"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Dicer1&lt;/i&gt; Depletion Leads to DNA Damage Accumulation and Cell Death in a RET/PTC3 Papillary Thyroid Cancer Mouse Model, Thereby Inhibiting Tumor Progression.","description":"Beyond well-known genetic drivers, microRNA dysregulation has emerged as a key contributor to thyroid tumorigenesis. Central to this process is <i>Dicer1</i>, a ribonuclease essential for microRNA maturation, whose expression is often reduced in papillary thyroid carcinoma (PTC). Evidence from previous studies suggest <i>Dicer1</i> functions as a context-dependent haplo-insufficient tumor suppressor gene: partial loss may promote tumor development, whereas complete loss may disrupt essential cellular functions, causing cell death and tumor suppression. However, the effects of partial or complete <i>Dicer1</i> loss in thyroid cancer remain unclear. To explore this, we genetically inactivated one (heterozygous) or both (homozygous) <i>Dicer1</i> alleles specifically in thyroid follicular cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:22:16.717Z","creation":"2026-05-01T03:11:07.435Z"},"accession":"S-EPMC12468101","cross_references":{"pubmed":["41002430"],"doi":["10.3390/cells14181465"]}}