biostudies-literatureRojo-Pardillo MHéger-Masson FoundationDavid et Alice Van Buuren FoundationRose et Jean Hoguet FoundationFund for Scientific Research - FRIA grantKing Baudouin Foundation - Fund Doctor J.P. NaetsFund for Scientific Research - Research creditJaumotte-Demoulin Foundation1465https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468101biostudies-literatureUnknown14(18)Beyond well-known genetic drivers, microRNA dysregulation has emerged as a key contributor to thyroid tumorigenesis. Central to this process is <i>Dicer1</i>, a ribonuclease essential for microRNA maturation, whose expression is often reduced in papillary thyroid carcinoma (PTC). Evidence from previous studies suggest <i>Dicer1</i> functions as a context-dependent haplo-insufficient tumor suppressor gene: partial loss may promote tumor development, whereas complete loss may disrupt essential cellular functions, causing cell death and tumor suppression. However, the effects of partial or complete <i>Dicer1</i> loss in thyroid cancer remain unclear. To explore this, we genetically inactivated one (heterozygous) or both (homozygous) <i>Dicer1</i> alleles specifically in thyroid follicular celCells&lt;i&gt;Dicer1&lt;/i&gt; Depletion Leads to DNA Damage Accumulation and Cell Death in a RET/PTC3 Papillary Thyroid Cancer Mouse Model, Thereby Inhibiting Tumor Progression.PMC12468101CDR J.0150.25FC36079CDR J.0123.232023-J1813300-2330202025-J1813300-0025101Kero JRojo-Pardillo MRobaye BAugenlicht AMaenhaut CDom Gfalse&lt;i&gt;Dicer1&lt;/i&gt; Depletion Leads to DNA Damage Accumulation and Cell Death in a RET/PTC3 Papillary Thyroid Cancer Mouse Model, Thereby Inhibiting Tumor Progression.Beyond well-known genetic drivers, microRNA dysregulation has emerged as a key contributor to thyroid tumorigenesis. Central to this process is <i>Dicer1</i>, a ribonuclease essential for microRNA maturation, whose expression is often reduced in papillary thyroid carcinoma (PTC). Evidence from previous studies suggest <i>Dicer1</i> functions as a context-dependent haplo-insufficient tumor suppressor gene: partial loss may promote tumor development, whereas complete loss may disrupt essential cellular functions, causing cell death and tumor suppression. However, the effects of partial or complete <i>Dicer1</i> loss in thyroid cancer remain unclear. To explore this, we genetically inactivated one (heterozygous) or both (homozygous) <i>Dicer1</i> alleles specifically in thyroid follicular cel2025-01-01T00:00:00Z2025 Sep2026-05-01T03:22:16.717Z2026-05-01T03:11:07.435ZS-EPMC124681014100243010.3390/cells14181465