{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66(12)"],"submitter":["Karouta C"],"pubmed_abstract":["<h4>Purpose</h4>Dopaminergic dysregulation plays a critical role in myopia development in animal models. Although its relevance to human myopia remains uncertain, the observation that methylphenidate hydrochloride (MPH)-a dopamine (DA) and norepinephrine (NE) uptake inhibitor-slows myopia progression in children suggests a possible link. This study aimed to investigate whether MPH can inhibit myopic growth and elucidate the underlying mechanisms using an animal model.<h4>Methods</h4>MPH was administered via oral, topical, or intravitreal routes for 7 days (minimum 5 per group) to chicks undergoing form-deprivation myopia (FDM). Myopia was assessed by refraction and axial length. Retinal DA and NE dynamics-including synthesis, release, uptake, breakdown (DA only), extracellular levels, and "],"journal":["Investigative ophthalmology & visual science"],"pagination":["52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468103"],"repository":["biostudies-literature"],"pubmed_title":["Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake."],"pmcid":["PMC12468103"],"pubmed_authors":["Thomson K","Morgan I","Booth L","Ashby R","Karouta C"],"additional_accession":[]},"is_claimable":false,"name":"Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.","description":"<h4>Purpose</h4>Dopaminergic dysregulation plays a critical role in myopia development in animal models. Although its relevance to human myopia remains uncertain, the observation that methylphenidate hydrochloride (MPH)-a dopamine (DA) and norepinephrine (NE) uptake inhibitor-slows myopia progression in children suggests a possible link. This study aimed to investigate whether MPH can inhibit myopic growth and elucidate the underlying mechanisms using an animal model.<h4>Methods</h4>MPH was administered via oral, topical, or intravitreal routes for 7 days (minimum 5 per group) to chicks undergoing form-deprivation myopia (FDM). Myopia was assessed by refraction and axial length. Retinal DA and NE dynamics-including synthesis, release, uptake, breakdown (DA only), extracellular levels, and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:13:09.168Z","creation":"2026-05-01T03:10:39.497Z"},"accession":"S-EPMC12468103","cross_references":{"pubmed":["40985800"],"doi":["10.1167/iovs.66.12.52"]}}