{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Butler MJ"],"pubmed_abstract":["<h4>Background</h4>Poor sleep (defined by short sleep duration or poor quality) is a common condition with potential serious health consequences. Exogenous melatonin supplements have been found to effectively improve poor sleep but have also been shown to have heterogeneity of treatment effects (HTEs) between individuals. Personalized N-of-1 trials, in which each participant is the unit of analysis, are ideal for identifying whether a treatment with high HTE is beneficial for each individual patient.<h4>Objective</h4>This study aimed to identify the feasibility, acceptability, and effectiveness of a series of personalized N-of-1 trials of melatonin for poor sleep.<h4>Methods</h4>This study consisted of 60 digital, personalized N-of-1 crossover trials comparing the effects of 3.0 mg and 0.5"],"journal":["JMIR formative research"],"pagination":["e58192"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468169"],"repository":["biostudies-literature"],"pubmed_title":["A Series of Personalized Melatonin Supplement Interventions for Poor Sleep: Feasibility Randomized Crossover Trial for Personalized N-of-1 Treatment."],"pmcid":["PMC12468169"],"pubmed_authors":["Miller D","Perrin A","Cheung YK","Butler MJ","Chandereng T","Ahn H","Slotnick S","Goodwin AM","Davidson KW","Rodillas J","Friel CP"],"additional_accession":[]},"is_claimable":false,"name":"A Series of Personalized Melatonin Supplement Interventions for Poor Sleep: Feasibility Randomized Crossover Trial for Personalized N-of-1 Treatment.","description":"<h4>Background</h4>Poor sleep (defined by short sleep duration or poor quality) is a common condition with potential serious health consequences. Exogenous melatonin supplements have been found to effectively improve poor sleep but have also been shown to have heterogeneity of treatment effects (HTEs) between individuals. Personalized N-of-1 trials, in which each participant is the unit of analysis, are ideal for identifying whether a treatment with high HTE is beneficial for each individual patient.<h4>Objective</h4>This study aimed to identify the feasibility, acceptability, and effectiveness of a series of personalized N-of-1 trials of melatonin for poor sleep.<h4>Methods</h4>This study consisted of 60 digital, personalized N-of-1 crossover trials comparing the effects of 3.0 mg and 0.5","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T21:13:57.1Z","creation":"2026-05-01T03:10:53.408Z"},"accession":"S-EPMC12468169","cross_references":{"pubmed":["41004640"],"doi":["10.2196/58192"]}}