{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Majumdar S"],"funding":["NEI NIH HHS","National Institute of Health"],"pagination":["1024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468242"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(9)"],"pubmed_abstract":["<b>Background/Objectives</b>: Glutamatergic neurotransmission is essential for the normal functioning of the retina. Photoreceptor to bipolar and bipolar to ganglion cell signaling is mediated by L-glutamate, which is stored in and released from vesicular glutamate transporter 1 (VGLUT1) containing synaptic vesicles. VGLUT1 is expressed postnatally, P2 onwards, and is required for the glutamatergic retinal wave observed between P10 and P12 in the developing mouse retina. P9-P13 postnatal age is critical for retinal development as VGLUT1 expressing ribbon synapses activate in the outer and inner plexiform layers, and rod/cone mediated visual signaling commences in that period. Although it has been hypothesized that glutamatergic extrinsic signaling drives cell cycle exit and initiates cellu"],"journal":["Brain sciences"],"pubmed_title":["Genetic Loss of VGLUT1 Alters Histogenesis of Retinal Glutamatergic Cells and Reveals Dynamic Expression of VGLUT2 in Cones."],"pmcid":["PMC12468242"],"funding_grant_id":["R37 EY001869","P30 EY002162","EY01869 and EY002162","R01 EY001869"],"pubmed_authors":["Majumdar S","Wu V"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Loss of VGLUT1 Alters Histogenesis of Retinal Glutamatergic Cells and Reveals Dynamic Expression of VGLUT2 in Cones.","description":"<b>Background/Objectives</b>: Glutamatergic neurotransmission is essential for the normal functioning of the retina. Photoreceptor to bipolar and bipolar to ganglion cell signaling is mediated by L-glutamate, which is stored in and released from vesicular glutamate transporter 1 (VGLUT1) containing synaptic vesicles. VGLUT1 is expressed postnatally, P2 onwards, and is required for the glutamatergic retinal wave observed between P10 and P12 in the developing mouse retina. P9-P13 postnatal age is critical for retinal development as VGLUT1 expressing ribbon synapses activate in the outer and inner plexiform layers, and rod/cone mediated visual signaling commences in that period. Although it has been hypothesized that glutamatergic extrinsic signaling drives cell cycle exit and initiates cellu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-02T03:11:10.305Z","creation":"2026-05-02T03:08:03.239Z"},"accession":"S-EPMC12468242","cross_references":{"pubmed":["41008384"],"doi":["10.3390/brainsci15091024"]}}