{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Drago L"],"pubmed_abstract":["<h4>Objectives</h4>To evaluate the in vitro antimicrobial activity of TiAB, a compound based on silver-bound titanium dioxide, against clinical isolates from dermatological infections.<h4>Methods</h4>We tested 155 strains clinically isolated from ulcers and skin infections, including MRSA, ESBL-producing <i>Enterobacterales</i>, and <i>P. aeruginosa</i>. MIC and MBC values were determined using broth microdilution according to CLSI guidelines. Time-kill assays were performed at 0.5×, 1×, and 2× MIC. Median values were used to describe susceptibility profiles.<h4>Results</h4>TiAB exhibited strong bactericidal activity against Gram-negative bacteria, including ESBL-positive <i>E. coli</i> and <i>K. pneumoniae</i>, with complete killing at 2× MIC (4-8%) within 4-8 h. Gram-positive pathogens e"],"journal":["Diseases (Basel, Switzerland)"],"pagination":["277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468273"],"repository":["biostudies-literature"],"pubmed_title":["In Vitro Activity of Silver-Bound Titanium Dioxide (Tiab) Against Multidrug-Resistant Bacteria from Dermatological Infections."],"pmcid":["PMC12468273"],"pubmed_authors":["Drago L","Deflorio L","Minasi V","Uslenghi A","Covi M","De La Motte LR","Giarritiello F"],"additional_accession":[]},"is_claimable":false,"name":"In Vitro Activity of Silver-Bound Titanium Dioxide (Tiab) Against Multidrug-Resistant Bacteria from Dermatological Infections.","description":"<h4>Objectives</h4>To evaluate the in vitro antimicrobial activity of TiAB, a compound based on silver-bound titanium dioxide, against clinical isolates from dermatological infections.<h4>Methods</h4>We tested 155 strains clinically isolated from ulcers and skin infections, including MRSA, ESBL-producing <i>Enterobacterales</i>, and <i>P. aeruginosa</i>. MIC and MBC values were determined using broth microdilution according to CLSI guidelines. Time-kill assays were performed at 0.5×, 1×, and 2× MIC. Median values were used to describe susceptibility profiles.<h4>Results</h4>TiAB exhibited strong bactericidal activity against Gram-negative bacteria, including ESBL-positive <i>E. coli</i> and <i>K. pneumoniae</i>, with complete killing at 2× MIC (4-8%) within 4-8 h. Gram-positive pathogens e","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T03:23:44.817Z","creation":"2026-05-01T03:11:25.928Z"},"accession":"S-EPMC12468273","cross_references":{"pubmed":["41002713"],"doi":["10.3390/diseases13090277"]}}