{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(18)"],"submitter":["Bilyalova A"],"pubmed_abstract":["This study investigates the adrenal gland structure and gene expression in <i>Acomys cahirinus</i> compared to <i>Mus musculus</i>, aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in <i>Acomys</i>, resembling the human adrenal cortex. Transcriptomic analysis revealed upregulation of key steroidogenic genes (C<i>yp17a1</i>, <i>Sult1e1</i>, <i>Hsd3b2</i>, <i>Defb18</i>, <i>Kiss1</i>, <i>H2-Ke6</i>), with validation by qRT-PCR and CAGE-seq. The gene <i>Nupl1</i> showed discordant results between RNA-seq and CAGE. Pathway analysis highlighted enrichment of steroidogenesis and adrenal metabolism. Notably, a GTEx-based comparison demonstrated that <i>Acomys</i> adrenal gene expression closely mirrors the expression in the human adrenal cortex, whereas <i>Mus musculus</i> samples diverged toward brain-specific signatures. These findings suggest that <i>Acomys cahirinus</i> represents a promising model for adrenal research, though further studies including single-cell transcriptomics and functional assays are warranted to fully establish its translational potential."],"journal":["Cells"],"pagination":["1431"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468302"],"repository":["biostudies-literature"],"pubmed_title":["Morphological and Transcriptomic Analyses of the Adrenal Gland in &lt;i&gt;Acomys cahirinus&lt;/i&gt;: A Novel Model for Murine Adrenal Physiology."],"pmcid":["PMC12468302"],"pubmed_authors":["Gusev O","Bilyalova A","Tychinin D","Bydanov A","Woroncow M","Titova A","Shagimardanova E","Kozlova O","Filimoshina D","Bilyalov A","Deviatiiarov R","Gazizova G","Mukhamedshina Y","Kiyasov A","Filatov N"],"additional_accession":[]},"is_claimable":false,"name":"Morphological and Transcriptomic Analyses of the Adrenal Gland in &lt;i&gt;Acomys cahirinus&lt;/i&gt;: A Novel Model for Murine Adrenal Physiology.","description":"This study investigates the adrenal gland structure and gene expression in <i>Acomys cahirinus</i> compared to <i>Mus musculus</i>, aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in <i>Acomys</i>, resembling the human adrenal cortex. Transcriptomic analysis revealed upregulation of key steroidogenic genes (C<i>yp17a1</i>, <i>Sult1e1</i>, <i>Hsd3b2</i>, <i>Defb18</i>, <i>Kiss1</i>, <i>H2-Ke6</i>), with validation by qRT-PCR and CAGE-seq. The gene <i>Nupl1</i> showed discordant results between RNA-seq and CAGE. Pathway analysis highlighted enrichment of steroidogenesis and adrenal metabolism. Notably, a GTEx-based comparison demonstrated that <i>Acomys</i> adrenal gene expression closely mirrors the expression in the human adrenal cortex, whereas <i>Mus musculus</i> samples diverged toward brain-specific signatures. These findings suggest that <i>Acomys cahirinus</i> represents a promising model for adrenal research, though further studies including single-cell transcriptomics and functional assays are warranted to fully establish its translational potential.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:23:12.754Z","creation":"2026-05-01T03:11:21.356Z"},"accession":"S-EPMC12468302","cross_references":{"pubmed":["41002397"],"doi":["10.3390/cells14181431"]}}