biostudies-literatureUnknown14(18)Bilyalova AThis study investigates the adrenal gland structure and gene expression in <i>Acomys cahirinus</i> compared to <i>Mus musculus</i>, aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in <i>Acomys</i>, resembling the human adrenal cortex. Transcriptomic analysis revealed upregulation of key steroidogenic genes (C<i>yp17a1</i>, <i>Sult1e1</i>, <i>Hsd3b2</i>, <i>Defb18</i>, <i>Kiss1</i>, <i>H2-Ke6</i>), with validation by qRT-PCR and CAGE-seq. The gene <i>Nupl1</i> showed discordant results between RNA-seq and CAGE. Pathway analysis highlighted enrichment of steroidogenesis and adrenal metabolism. Notably, a GTEx-based comparison demonstrated that <i>Acomys</i> adrenal gene expression closely mirrors the expression in the human adrCells1431https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468302biostudies-literatureMorphological and Transcriptomic Analyses of the Adrenal Gland in <i>Acomys cahirinus</i>: A Novel Model for Murine Adrenal Physiology.PMC12468302Gusev OBilyalova ATychinin DBydanov AWoroncow MTitova AShagimardanova EKozlova OFilimoshina DBilyalov ADeviatiiarov RGazizova GMukhamedshina YKiyasov AFilatov NfalseMorphological and Transcriptomic Analyses of the Adrenal Gland in <i>Acomys cahirinus</i>: A Novel Model for Murine Adrenal Physiology.This study investigates the adrenal gland structure and gene expression in <i>Acomys cahirinus</i> compared to <i>Mus musculus</i>, aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in <i>Acomys</i>, resembling the human adrenal cortex. Transcriptomic analysis revealed upregulation of key steroidogenic genes (C<i>yp17a1</i>, <i>Sult1e1</i>, <i>Hsd3b2</i>, <i>Defb18</i>, <i>Kiss1</i>, <i>H2-Ke6</i>), with validation by qRT-PCR and CAGE-seq. The gene <i>Nupl1</i> showed discordant results between RNA-seq and CAGE. Pathway analysis highlighted enrichment of steroidogenesis and adrenal metabolism. Notably, a GTEx-based comparison demonstrated that <i>Acomys</i> adrenal gene expression closely mirrors the expression in the human adr2025-01-01T00:00:00Z2025 Sep2026-05-01T03:23:12.754Z2026-05-01T03:11:21.356ZS-EPMC124683024100239710.3390/cells14181431