{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Souza JS"],"funding":["NIEHS NIH HHS","NIMH NIH HHS","NINDS NIH HHS","Department of Defense","NIH HHS"],"pagination":["1407"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12468339"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(18)"],"pubmed_abstract":["Thyroid hormones (THs) are essential for brain development, and their dysregulation is associated with cognitive deficits and neurodevelopmental disorders. Down syndrome (DS), caused by trisomy 21, is frequently associated with thyroid dysfunction and impaired neurogenesis. Here, we investigated THs signaling dynamics during neural differentiation using human induced pluripotent stem cells (hiPSCs) derived from individuals with DS and controls. We analyzed the gene expression of key THs regulators-deiodinases, transporters, and receptors-and downstream target genes in hiPSCs, hiPSC-derived neural progenitor cells (NPCs), hiPSC-derived astrocytes, and hiPSC-derived neurons. DS-derived hiPSCs, hiPSC-derived NPCs, and hiPSC-derived neurons exhibited 2- to 7-fold increases in the gene expressi"],"journal":["Cells"],"pubmed_title":["Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro."],"pmcid":["PMC12468339"],"funding_grant_id":["1R01MH128365-24","R01 MH123828","1R01NS105969-19","1R01NS123642-21","1R01MH123828-21","R01 ES033636","R01 NS123642","R01 MH127077","1R01MH127077-22","R01 NS105969","R56 MH128365","W81XWH2110306","1R01ES033636-22"],"pubmed_authors":["Guerra BS","Giannocco G","de Souza JS","Muotri AR","Amelinez-Robles N","Sanchez-Sanchez S"],"additional_accession":[]},"is_claimable":false,"name":"Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro.","description":"Thyroid hormones (THs) are essential for brain development, and their dysregulation is associated with cognitive deficits and neurodevelopmental disorders. Down syndrome (DS), caused by trisomy 21, is frequently associated with thyroid dysfunction and impaired neurogenesis. Here, we investigated THs signaling dynamics during neural differentiation using human induced pluripotent stem cells (hiPSCs) derived from individuals with DS and controls. We analyzed the gene expression of key THs regulators-deiodinases, transporters, and receptors-and downstream target genes in hiPSCs, hiPSC-derived neural progenitor cells (NPCs), hiPSC-derived astrocytes, and hiPSC-derived neurons. DS-derived hiPSCs, hiPSC-derived NPCs, and hiPSC-derived neurons exhibited 2- to 7-fold increases in the gene expressi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:22:23.906Z","creation":"2026-05-01T03:11:08.958Z"},"accession":"S-EPMC12468339","cross_references":{"pubmed":["41002374"],"doi":["10.3390/cells14181407"]}}