{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao J"],"funding":["the Basic Research Program of Shanxi (Free Exploration Categories)","the National Natural Science Foundation of China Youth Science Fund Project"],"pagination":["1070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(9)"],"pubmed_abstract":["<h4>Background/objectives</h4>The JCHAIN (immunoglobulin-linked chain) is a multimeric IgA and IgM-linked chain whose involvement in oncogenesis and immunomodulation is unknown. The goal of this work was to conduct a comprehensive pan-cancer analysis of the <i>JCHAIN</i> to determine its expression profile, prognostic significance, immune infiltration, and function in diverse malignancies.<h4>Methods</h4>We performed pan-cancer analysis of gene expression data and protein expression data of <i>JCHAIN</i> using multiple databases, and analysed the prognostic significance of <i>JCHAIN</i> in a variety of cancers using univariate Cox analysis and Kaplan-Meier tools. The relationship between <i>JCHAIN</i> and immune cell infiltration was analysed via the TISIDB and TIMER websites, while single"],"journal":["Genes"],"pubmed_title":["&lt;i&gt;JCHAIN&lt;/i&gt;: A Prognostic Marker Based on Pan-Cancer Analysis to Inhibit Breast Cancer Progression."],"pmcid":["PMC12469470"],"funding_grant_id":["31500962","202103021224022"],"pubmed_authors":["Zhang Z","Chen W","Wang Y","Zhao J","Li L"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;JCHAIN&lt;/i&gt;: A Prognostic Marker Based on Pan-Cancer Analysis to Inhibit Breast Cancer Progression.","description":"<h4>Background/objectives</h4>The JCHAIN (immunoglobulin-linked chain) is a multimeric IgA and IgM-linked chain whose involvement in oncogenesis and immunomodulation is unknown. The goal of this work was to conduct a comprehensive pan-cancer analysis of the <i>JCHAIN</i> to determine its expression profile, prognostic significance, immune infiltration, and function in diverse malignancies.<h4>Methods</h4>We performed pan-cancer analysis of gene expression data and protein expression data of <i>JCHAIN</i> using multiple databases, and analysed the prognostic significance of <i>JCHAIN</i> in a variety of cancers using univariate Cox analysis and Kaplan-Meier tools. The relationship between <i>JCHAIN</i> and immune cell infiltration was analysed via the TISIDB and TIMER websites, while single","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-03T03:12:30.316Z","creation":"2026-05-03T03:10:41.04Z"},"accession":"S-EPMC12469470","cross_references":{"pubmed":["41010015"],"doi":["10.3390/genes16091070"]}}