biostudies-literatureZhao Jthe Basic Research Program of Shanxi (Free Exploration Categories)the National Natural Science Foundation of China Youth Science Fund Project1070https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469470biostudies-literatureUnknown16(9)<h4>Background/objectives</h4>The JCHAIN (immunoglobulin-linked chain) is a multimeric IgA and IgM-linked chain whose involvement in oncogenesis and immunomodulation is unknown. The goal of this work was to conduct a comprehensive pan-cancer analysis of the <i>JCHAIN</i> to determine its expression profile, prognostic significance, immune infiltration, and function in diverse malignancies.<h4>Methods</h4>We performed pan-cancer analysis of gene expression data and protein expression data of <i>JCHAIN</i> using multiple databases, and analysed the prognostic significance of <i>JCHAIN</i> in a variety of cancers using univariate Cox analysis and Kaplan-Meier tools. The relationship between <i>JCHAIN</i> and immune cell infiltration was analysed via the TISIDB and TIMER websites, while singleGenes&lt;i&gt;JCHAIN&lt;/i&gt;: A Prognostic Marker Based on Pan-Cancer Analysis to Inhibit Breast Cancer Progression.PMC1246947031500962202103021224022Zhang ZChen WWang YZhao JLi Lfalse&lt;i&gt;JCHAIN&lt;/i&gt;: A Prognostic Marker Based on Pan-Cancer Analysis to Inhibit Breast Cancer Progression.<h4>Background/objectives</h4>The JCHAIN (immunoglobulin-linked chain) is a multimeric IgA and IgM-linked chain whose involvement in oncogenesis and immunomodulation is unknown. The goal of this work was to conduct a comprehensive pan-cancer analysis of the <i>JCHAIN</i> to determine its expression profile, prognostic significance, immune infiltration, and function in diverse malignancies.<h4>Methods</h4>We performed pan-cancer analysis of gene expression data and protein expression data of <i>JCHAIN</i> using multiple databases, and analysed the prognostic significance of <i>JCHAIN</i> in a variety of cancers using univariate Cox analysis and Kaplan-Meier tools. The relationship between <i>JCHAIN</i> and immune cell infiltration was analysed via the TISIDB and TIMER websites, while single2025-01-01T00:00:00Z2025 Sep2026-05-03T03:12:30.316Z2026-05-03T03:10:41.04ZS-EPMC124694704101001510.3390/genes16091070