biostudies-literatureXie HJiangsu Funding Program for Excellent Postdoctoral TalentAutism Research Special Fund of Zhejiang Foundation For Disabled PersonsNational Natural Science Foundation of China1112https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469495biostudies-literatureUnknown16(9)<b>Background:</b> Obesity poses a significant threat to human health and is commonly caused by excessive dietary intake. Phosphatidic acid (PA) is one of the simplest diacylglycerol phospholipids, serving as a crucial precursor for the synthesis of triglycerides and other complex phospholipids. PA is also an important intermediate product in the process of fat digestion and absorption. Studies have shown that PA has muscle-building and fat-reducing effects, but it is currently unclear whether it can combat obesity induced by a high-fat, high-sugar diet (HFD). <b>Methods:</b> Using a model of obesity induced by a high-fat high-sugar diet, we found that the addition of PA to food could reverse HFD-induced obesity. <b>Results:</b> Addition of PA to food can reverse obesity induced by a high-GenesPhosphatidic Acid Reverses Obesity Induced by a High-Fat, High-Sugar Diet at the Transcriptional Level.PMC124694953237078820220022023ZB782Liao YXie HCheng QTian XfalsePhosphatidic Acid Reverses Obesity Induced by a High-Fat, High-Sugar Diet at the Transcriptional Level.<b>Background:</b> Obesity poses a significant threat to human health and is commonly caused by excessive dietary intake. Phosphatidic acid (PA) is one of the simplest diacylglycerol phospholipids, serving as a crucial precursor for the synthesis of triglycerides and other complex phospholipids. PA is also an important intermediate product in the process of fat digestion and absorption. Studies have shown that PA has muscle-building and fat-reducing effects, but it is currently unclear whether it can combat obesity induced by a high-fat, high-sugar diet (HFD). <b>Methods:</b> Using a model of obesity induced by a high-fat high-sugar diet, we found that the addition of PA to food could reverse HFD-induced obesity. <b>Results:</b> Addition of PA to food can reverse obesity induced by a high-2025-01-01T00:00:00Z2025 Sep2026-07-05T03:13:14.564Z2026-07-05T03:11:54.024ZS-EPMC124694954101005710.3390/genes16091112