biostudies-literatureBusse JFHeinrich und Alma Vogelsang Stiftung BochumEvangelisches Studienwerk e.V. Villigst9019https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469665biostudies-literatureUnknown26(18)Global cerebral hypoxia triggers (mal-)adaptive responses that can lead to neuronal damage. This study evaluated edaravone's neuroprotective effects in a rat hypoxia model, focusing on sex differences, treatment durations, and behavioral outcomes. Male and female rats underwent global cerebral hypoxia induced by rocuronium, with post-hypoxia edaravone treatment. Motor coordination and activity were assessed through exploratory behavior tests. Histological analyses evaluated neuronal integrity and apoptosis, while microglial activity and gene expression were analyzed via immunofluorescence and qPCR. Edaravone showed transient neuroprotective effects on motor behavior and early immune responses, particularly in the cerebellum and hippocampus. No gross morphological damage was observed, thougInternational journal of molecular sciencesTherapeutic Potential of Edaravone for Neuroprotection Following Global Cerebral Hypoxia.PMC12469665not applicableHamacher LIStahlke SFrai JWeber TTheiss CBusse JFMatschke VHerzog-Niescery JfalseTherapeutic Potential of Edaravone for Neuroprotection Following Global Cerebral Hypoxia.Global cerebral hypoxia triggers (mal-)adaptive responses that can lead to neuronal damage. This study evaluated edaravone's neuroprotective effects in a rat hypoxia model, focusing on sex differences, treatment durations, and behavioral outcomes. Male and female rats underwent global cerebral hypoxia induced by rocuronium, with post-hypoxia edaravone treatment. Motor coordination and activity were assessed through exploratory behavior tests. Histological analyses evaluated neuronal integrity and apoptosis, while microglial activity and gene expression were analyzed via immunofluorescence and qPCR. Edaravone showed transient neuroprotective effects on motor behavior and early immune responses, particularly in the cerebellum and hippocampus. No gross morphological damage was observed, thoug2025-01-01T00:00:00Z2025 Sep2026-05-02T03:20:42.358Z2026-05-02T03:11:50.206ZS-EPMC124696654100958210.3390/ijms26189019