{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang D"],"funding":["Natural Science Foundation of Inner Mongolia","Doctoral Start-up Fund Project of Inner Mongolia Medical University","Key Project of Inner Mongolia Medical University","National Natural Science Foundation of China","Foundation of Inner Mongolia Medical University"],"pagination":["750"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12469758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["Hydroxyl radicals (·OH) offer exceptional potential for cancer treatment through reactive oxygen species (ROS) amplification and apoptotic induction. However, conventional Fe-based metal-organic framework (Fe-MOF) nanomaterials are limited by inadequate Fe<sup>2+</sup> concentrations, resulting in suboptimal Fenton catalytic performance. This study presents concave octahedral Fe-MOF nanomaterials with integrated bimetallic Fe/Zn centers through controlled solvothermal synthesis. The nanoplatform exhibits high specific surface area (559 m<sup>2</sup>/g) and 5-fluorouracil (5-FU) loading efficiency (58.7%). These structural properties establish it as a potential nanobuilding block for constructing stimuli-responsive gels. With optimized Fe<sup>2+</sup> content (57.3%), the Fe-MOF material sh"],"journal":["Gels (Basel, Switzerland)"],"pubmed_title":["Concave-Octahedral Fe&lt;sup&gt;2+&lt;/sup&gt;-Rich Fe-MOF/FU Nano-Blocks with Enhanced pH-Responsive Nanozyme Activity Toward Stimuli-Responsive Gels for Chemo-Chemodynamic Synergistic Therapy."],"pmcid":["PMC12469758"],"funding_grant_id":["82360824","YKD2025ZD009","YKD2025BSQD022, YKD2024BSQD009","2024QN05006","YKD2023MS082"],"pubmed_authors":["Bao L","Qi H","Guo H","Wang D","Cheng R","Wu S","Xu C","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Concave-Octahedral Fe&lt;sup&gt;2+&lt;/sup&gt;-Rich Fe-MOF/FU Nano-Blocks with Enhanced pH-Responsive Nanozyme Activity Toward Stimuli-Responsive Gels for Chemo-Chemodynamic Synergistic Therapy.","description":"Hydroxyl radicals (·OH) offer exceptional potential for cancer treatment through reactive oxygen species (ROS) amplification and apoptotic induction. However, conventional Fe-based metal-organic framework (Fe-MOF) nanomaterials are limited by inadequate Fe<sup>2+</sup> concentrations, resulting in suboptimal Fenton catalytic performance. This study presents concave octahedral Fe-MOF nanomaterials with integrated bimetallic Fe/Zn centers through controlled solvothermal synthesis. The nanoplatform exhibits high specific surface area (559 m<sup>2</sup>/g) and 5-fluorouracil (5-FU) loading efficiency (58.7%). These structural properties establish it as a potential nanobuilding block for constructing stimuli-responsive gels. With optimized Fe<sup>2+</sup> content (57.3%), the Fe-MOF material sh","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-01T03:23:30.696Z","creation":"2026-05-01T03:11:23.731Z"},"accession":"S-EPMC12469758","cross_references":{"pubmed":["41002524"],"doi":["10.3390/gels11090750"]}}